Human Umbilical Cord Mesenchymal Stem-Cell Therapy to Increase the Density of Osteoporotic Mandibular Bone

Nike Hendrijantini, NIDN. 0006105908 and Poedjo Hartono, NIDN. 8823800016 and Muhammad Dimas Aditya Ari, NIM. 020911007 and Fedik Abdul Rantam, NIDN. 0010035907 (2019) Human Umbilical Cord Mesenchymal Stem-Cell Therapy to Increase the Density of Osteoporotic Mandibular Bone. European Journal of Dentistry. pp. 58-63. ISSN 1305-7464

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Abstract

Objective The aim of this study is to evaluate the feasibility of human umbilical cord mesenchymal stem-cell (hUCMSC) therapy in increasing osteoporotic mandibular bone density in a rat model by determining changes in alkaline phosphatase (ALP), osteocalcin, type 1 collagen, and trabecular bone area after treatment. Materials and Methods This research adopted an experimental posttest-only control group design. Thirty female Wistar rats were randomly divided into six groups, namely, a control group with rats postsham surgery (T1), osteoporotic model postovariectomy rats (T2), postovariectomy rats 4 weeks after gelatin injection (T3), postovariectomy rats 8 weeks after gelatin injection (T4), postovariectomy rats 4 weeks after hUCMSC injection (T5), and postovariectomy rats 8 weeks after hUCMSC injection (T6). The rats were all sacrificed for histological and immunohistochemical examinations of ALP, osteocalcin, type 1 collagen, and trabecular bone area. Results Increased expression of ALP, type 1 collagen, and osteocalcin, as well as increased trabecular bone area, was observed in the treatment groups compared with that in the osteoporotic groups. Conclusion hUCMSCs produce significant osteogenic effects and increase osteoporotic mandibular bone density in the animal model. Increases in bone density are demonstrated by the higher levels of ALP, osteocalcin, and type 1 collagen, as well as increases in the trabecular bone area.

Item Type: Article
Uncontrolled Keywords: human, mandibular, osteoporosis
Subjects: R Medicine
R Medicine > RK Dentistry
R Medicine > RK Dentistry > RK641-667 Prosthetic dentistry. Prosthodontics
Divisions: 02. Fakultas Kedokteran Gigi > Prosthodontics
Creators:
CreatorsNIM/NIDN
Nike Hendrijantini, NIDN. 0006105908UNSPECIFIED
Poedjo Hartono, NIDN. 8823800016UNSPECIFIED
Muhammad Dimas Aditya Ari, NIM. 020911007UNSPECIFIED
Fedik Abdul Rantam, NIDN. 0010035907UNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 23 Sep 2019 08:46
Last Modified: 23 Sep 2019 08:46
URI: http://repository.unair.ac.id/id/eprint/87166
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