New cis-ent-clerodanes from Linaria Japonica

Retno Widowati, NIDN. 0005017701 and Sachiko Sugimoto and Yoshi Yamano and Sukardiman, NIDN. 0001096305 and Hideaki Otsuka and Katsuyoshi Matsunami (2015) New cis-ent-clerodanes from Linaria Japonica. Phytochemistry Letters, 14. pp. 56-62. ISSN 1874-3900

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Five new cis-ent-clerodanes, linarenones A–E (1–5) and two known compounds (6 and 7) were isolated from whole plant of Linaria japonica. The structures of these compounds were determined by various spectroscopic analyses (UV, IR, HR–ESI–MS, 1D and 2D NMR). The absolute configuration of five new diterpenoids was confirmed by circular dichroism (CD) analysis and chemical conversion. Cytotoxicity of the isolated compounds against A549 cell lines and Leishmania major were evaluated. The new cis-entclerodane 3 was found to be moderately active against A549 cell lines, and new cis-ent-clerodanes 1,6 and desacetyl-linarienone (7) were active against L. major.

Item Type: Article
Uncontrolled Keywords: Linaria japonica, Linarenone, Cytotoxicity, Leishmania, cis-ent-Clerodane
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Retno Widowati, NIDN. 0005017701UNSPECIFIED
Sachiko SugimotoUNSPECIFIED
Sukardiman, NIDN. 0001096305UNSPECIFIED
Katsuyoshi MatsunamiUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 22 Oct 2019 01:05
Last Modified: 22 Oct 2019 01:05
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