New Isolinariins C, D and E, Flavonoid Glycosides from Linaria japonica

Rr. Retno Widyowati, NIDIN. 0005017701 and Sachiko Sugimoto and Yoshi Yamano and Sukardiman, NIDN. 0001096305 and Hideaki Otsuka and Katsuyoshi Matsunami (2016) New Isolinariins C, D and E, Flavonoid Glycosides from Linaria japonica. Chemical & Pharmaceutical Bulletin, 64 (5). pp. 517-521. ISSN 0009-2363

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Three new flavonoid glycosides named isolinariins C, D and E (1–3), two known flavonoid glycosides (4,5) and three known flavonoids (6–8) were isolated from the whole plant of Linaria japonica. The structures of these compounds were determined mainly by spectroscopic analyses. The bioactivities of these isolated compounds were evaluated for their inhibitory activities against human cell line A549, collagenase, and advanced glycation end product (AGE) formation. Among the isolated compounds, isolinariins C, D and E (1, 2 and 3) showed inhibition toward AGE formation (IC50 values of 34.8, 35.0 and 19.5 µM, respectively). And linariin (4), pectolinarin (5) and luteolin (8) were found to be active against collagenase with IC50 values of 79.4, 78.6 and 40.5 µM, respectively, without significant cytotoxicity at these concentrations.

Item Type: Article
Uncontrolled Keywords: Linaria japonica; cytotoxicity; collagenase; advanced glycation end product; flavonoid glycoside
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Rr. Retno Widyowati, NIDIN. 0005017701UNSPECIFIED
Sachiko SugimotoUNSPECIFIED
Sukardiman, NIDN. 0001096305UNSPECIFIED
Katsuyoshi MatsunamiUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 22 Oct 2019 01:02
Last Modified: 22 Oct 2019 01:02
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