Idha Kusumawati and Kresma Oky Kurniawan and Subhan Rullyansyah and Tri Anggono Prijo and Rr. Retno Widyowati and Juni Ekowati and Eka Pramyrtha Hestianah and Suprapto Maat and Katsuyoshi Matsunamif (2018) Anti-aging properties of Curcuma heyneana Valeton & Zipj: A scientific approach to its use in Javanese tradition. Journal of Ethnopharmacology, 225. pp. 64-70. ISSN 0378-8741

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Abstract

Ethnopharmacological relevance:Temu giring, the rhizome ofCurcuma heyneanaValeton & Zipj (C. heyneana), isnative to tropical regions, especially in Indonesia. It is traditionally used as a skin care, for cosmetic and bodyfreshness, in Javanese and Balinese women, and has many other bioactivities such as antioxidant, anticancer andantiinflammatory.Aim of the study:The purpose of this study was to determine the antiaging activity of C. heyneana to prove itstraditional use.Materials and methods:The antioxidant activity was determined using the DPPH free radical method, and anti-aging activity was examined using in vitro assays such as tyrosinase inhibitor and collagenase inhibitor. In vivotests were performed by observing histomorphologic changes in rat skin exposed to Ultraviolet (UV) rays. Thetotal curcuminoid contents and chromatographic profiles were determined by Thin Layer Chromatography (TLC)–densitometry.Results:In all in vitro assays, all of the extracts showed a dose-dependent manner in thefinal concentrationrange from 62.5 to 500 μg/mL for DPPH assay and 31.25 to 250 μg/mL for tyrosinase inhibition and collagenaseinhibition assay. Curcuminoid (CUR), the active principle ofCurcumagenus shows antioxidant, tyrosinase in-hibitor and collagenase inhibitor activity greater than allC. heyneanaextracts. The in vivo assay results showedthat the topical application of the crude extract ofC. heyneanaproduced significant improvement effects on theUV-induced skin structure damage. The total CUR content was correlated with the anti-aging activity ofCurcumaheyneana.Conclusions:The results show thatC. heyneanacontains antioxidant compounds and has potent anti-aging ac-tivity, indicating that it can be used as an anti-aging drug candidate or as a phyto-cosmeceutical.

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