The Effect of Combination Spirulina–chitosan on Angiogenesis, Osteoclast, and Osteoblast Cells in Socket Models of Hyperglycemic Rattus norvegicus

Nike Hendrijantini, NIDN. 0006105908 and Rostiny, NIDN. 0020095402 and Mefina Kuntjoro, NIDN. 0029097905 and KENT SIDHARTA, 021411133008 and DEA SYARAFINA PUTRI WIYONO, 021411131034 and ALOCITTA ANINDYANARI, 021411131057 and Sherman Salim, NIDN. 8833370018 (2018) The Effect of Combination Spirulina–chitosan on Angiogenesis, Osteoclast, and Osteoblast Cells in Socket Models of Hyperglycemic Rattus norvegicus. Contemporary Clinical Dentistry, 20 (20). pp. 1-5. ISSN 0976-2361

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Abstract

Background: Prolongation of the inflammatory process in hyperglycemic interferes with bone formation, inhibits the healing process, and triggers bone resorption. A combination of spirulina and chitosan in the tooth socket of Rattus norvegicus is expected to promote the bone remodeling process. This study aimed to evaluate the effect of spirulina and chitosan on angiogenesis, osteoclast, and osteoblast cell in tooth socket models of type 1 diabetes. Materials and Methods: A laboratory‑based experiment involving 36 R. norvegicus, divided into three groups (nondiabetes mellitus (DM), uncontrolled DM, and controlled DM) and further divided into six subgroups. The controlled groups (K1, K2, and K3) were induced with 3% carboxymethyl cellulose Na, while the treated groups were induced with 12% spirulina and 20% chitosan. On the 14th day, the mandibles of the rats were removed. The capillary lumen, osteoblasts, and osteoclast cells were counted by hypothalamic–pituitary–adrenal examination and the results analyzed by means of Shapiro–Wilk, Levene’s, one‑way ANOVA, and post hoc Tukey’s honestly significant difference test. Results: There was a significant increment in the number of capillary lumen, osteoblast cells, and a decrease in osteoclasts in all three treated groups (P1, P2, and P3). Conclusions: A combination of spirulina and chitosan can effectively promote the healing process in postextraction sockets of type 1 DM R. norvegicus.

Item Type: Article
Uncontrolled Keywords: Bone, chitosan, diabetes mellitus, spirulina, wound healing
Subjects: R Medicine
R Medicine > RK Dentistry
R Medicine > RK Dentistry > RK641-667 Prosthetic dentistry. Prosthodontics
Divisions: 02. Fakultas Kedokteran Gigi > Prosthodontics
Creators:
CreatorsNIM/NIDN
Nike Hendrijantini, NIDN. 0006105908UNSPECIFIED
Rostiny, NIDN. 0020095402UNSPECIFIED
Mefina Kuntjoro, NIDN. 0029097905UNSPECIFIED
KENT SIDHARTA, 021411133008UNSPECIFIED
DEA SYARAFINA PUTRI WIYONO, 021411131034UNSPECIFIED
ALOCITTA ANINDYANARI, 021411131057UNSPECIFIED
Sherman Salim, NIDN. 8833370018UNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 26 Sep 2019 07:25
Last Modified: 26 Sep 2019 07:25
URI: http://repository.unair.ac.id/id/eprint/87361
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