New methyl threonolactones and pyroglutamates of Spilanthes acmella

Rr. Retno Widyowati, NIDN. 0005017701 and Sachiko Sugimoto and Yoshi Yamano and Hideaki Otsuka and Katsuyoshi Matsunami (2015) New methyl threonolactones and pyroglutamates of Spilanthes acmella. In: The Inaugural Symposiumof the Phytochemical Society of Asia, 30 Agustus - 2 September 2015, Tokushima Bunri University. (Unpublished)

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[Objective] Spilanthes acmella is a medicinal plant that distributed in the tropical and subtropical regions with rich source of therapeutic and medicinal constituents. The main constituents, "spilanthol” and “ acmellonate”, are used to reduce the pain associated with toothaches and induce saliva secretion. It is also used traditionally as treatment of rheumatism, tongue paralysis, antipyretic, sore throat, and gum infections [1]. It contains phytosterols, essential oils, sesquiterpenes, α and β-bisabolenes and cadinenes, flavonoid glucoside and a mixture of long chain hydrocarbons. In recent years, other bioactive metabolites have been isolated as vanillic acid, trans-ferulic acid, trans-isofcrulic acid, scopolelin, 3-acetylaleuritolic acid and β-sitostenone[2], [Methods] The aerial parts of Spilanthes acmella were collected in Purwodadi, Indonesia, then extracted with methanol. The obtained methanol extract was concentrated and partitioned with n-hexane, ethyl acetate, and 1-butanol. [Results] On investigation of the 1-butanol layer of this plant, a new methyl threonolactone glucoside (1), a new methyl threonolactone fructofuranoside (2) and two new pyroglutamates (3, 4) along with 2-C-methyl-D-threono-1,4-lactone (5), 2-deoxy-D-ribono-1,4-lactone (6), methylpyroglutamate (7), dendranthemoside A (8), dendranthemoside B (9), ampelopsisionoside (10),icariside B2 (11), benzyl-α-L-arabinopyranosyl-( l-6)-β-D-glucopyranoside (12) and chicoriin (13) were isolated by various chromatographic techniques such as silica gel, ODS column chromatography and HPLC. The structures of these compounds were determined as follows by spectrometric analysis (UV, IR, ID- and 2D-NMR, and HR-ESI-MS).

Item Type: Conference or Workshop Item (Speech)
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Rr. Retno Widyowati, NIDN. 0005017701UNSPECIFIED
Sachiko SugimotoUNSPECIFIED
Katsuyoshi MatsunamiUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 21 Oct 2019 02:09
Last Modified: 21 Oct 2019 02:09
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