Rr. Retno Widyowati, NIDN. 0005017701 and Wiwied Ekasari, NIDN. 0022016902 and Nenny Purwitasari, NIDN. 0019048006 (2018) Benzopyrones and Fatty Acids from Ethyl Acetate Layer of Spilanthes acmella Murr. In: Bromo Conference, Symposium on Natural Products & Biodiversity, 11-12 Juli 2018, Surabaya. (Unpublished)

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Abstract

Background:The main constituents from the whole aerial parts, flower heads and roots of Spilanthes acmella Murr. (Compositae) yield “spilanthol” and “acmellonate,” they are sometimes used to reduce the pain associated with toothaches, induce saliva secretion and is a powerful insecticide and local anesthetic. It also has an important source of highly valuable bioactive compounds such as fatty acids, phenolics, coumarin (scopoletin), triterpenoids and flavonoids. Objective: This research has purpose to find the chemical constituents containin the ethyl acetate layer of the 70% ethanol extract of Spilantel acmella. Methods: The structures of these compounds were isolated by various chromatographic techniques such as silica gel, ODS, HPLC and determined as follows by spectrometric analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR)and based on chemical evidences. Results: The investigation of the ethyl acetate layer of this plant has demonstrated the present of a benzene propanoic (1), 9,11-octadecadienoic methyl ester acid (2), tridecanoic methyl ester acid (3), and pentadecanoicacid (4).Conclusion: The ethyl acetate layer of Spilanthes acmella contains benzopyrones and fatty acids.

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