Association of Protein Expression p53 Mutants with Regional Lymph Gland Status on type III Carcinoma Nasofaring Patients

Riza Aswarin and Muhtarum Yusuf, NIDN. 8857900016 and M.S. Wiyadi (2018) Association of Protein Expression p53 Mutants with Regional Lymph Gland Status on type III Carcinoma Nasofaring Patients. Indian Journal of Otolaryngology and Head & Neck Surgery, 70 (3). pp. 405-409. ISSN 2231-3796

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Official URL: https://link.springer.com/article/10.1007/s12070-0...

Abstract

Nasopharyngeal carcinoma (NPC) is a malignant disease originating from the nasopharyngeal epithelial cells. The molecular mechanism of cancer occurrence is a change in the oncogene and tumor suppressor genes. One of the tumor suppressor genes that mutate in cancer cells is the mutant p53 gene. One of nasopharyngeal carcinoma progression is determined by the status of regional lymph gland. The enormous regional lymph node has a poor prognosis. To analyze the expression of the mutant p53 protein in Nasopharyngeal carcinoma (NPC) that correlated with regional lymph gland status (N) as a clinical manifestation. Expression of mutant p53 protein from NPC tissue paraffin block with immunohistochemical cracking technique was using monoclonal rabbit Anti Human p53 clone 318-6-11 (Dako, North America, Inc., 6392 Via Real Carpinteria, CA 93013 USA), microscope light binoculars was assessed visually by an Anatomical Pathology Consultant. Positive expression of p53 mutants was obtained 57.58% from all the sample in N0 by 0 subjects, N1 was 6 subjects, N2 was 7 subjects, and N3 was 7 subjects. The results of Mann–Whitney U test was p = 0.706, then there was no significant (p > 0.05) correlation between positive expression of p53 protein in type III WHO NPC with the regional lymph gland were N0, N1, N2, and N3. There was no significant between expression protein p53 mutants’ regional and lymph gland in type III WHO NPC.

Item Type: Article
Uncontrolled Keywords: Nasopharyngeal carcinoma, Protein p53 mutants, Lymph mutants
Subjects: R Medicine > R Medicine (General)
R Medicine > RF Otorhinolaryngology
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit THT
Creators:
CreatorsNIM/NIDN
Riza AswarinUNSPECIFIED
Muhtarum Yusuf, NIDN. 8857900016muhtarum.yusuf@fk.unair.ac.id
M.S. WiyadiUNSPECIFIED
Depositing User: hanif kurniawan
Date Deposited: 04 Oct 2019 08:24
Last Modified: 04 Oct 2019 08:24
URI: http://repository.unair.ac.id/id/eprint/87801
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