Skin Penetration of Ubiquinone (Co-Q10) In Nanoemulsion Delivery System Using Virgin Cocunut Oil (Vco)

Tristiana Erawati, NIDN. 0018055803 and Widji Soeratri, NIDN. 0006105103 and Noorma Rosita, NIDN. 0025126506 (2018) Skin Penetration of Ubiquinone (Co-Q10) In Nanoemulsion Delivery System Using Virgin Cocunut Oil (Vco). International Journal of Drug Delivery Technology, 8 (2). pp. 77-79. ISSN 0975 4415

[img] Text (FULLTEXT)
Artikel C-3.pdf
Available under License Creative Commons Attribution Non-commercial.

Download (1MB)
[img] Text (SIMILARITY)
C-03 Result - Skin Penetration of Ubiquinone (Co-Q10) In Nanoemulsi on Delivery System Using Virgin Cocunut Oil (Vco).pdf

Download (1MB)
[img] Text (PEER REVIEW)
Val C-3.pdf

Download (1MB)
Official URL: http://impactfactor.org/PDF/IJDDT/8/IJDDT,Vol8,Iss...

Abstract

Ubiquinone (co-Q10) is a topical anti-aging with low solubility in water, so its penetration into the skin is also low. To increase its penetration ubiquinone (co-Q10) was loaded in the nanoemulsion delivery system using virgin coconut oil (VCO) as oil phase. Ubiquinone (co-Q10) in nanoemulsion formula consists of; ubiquinone (co-Q10), Tween 80, Span 80, ethanol 96%, VCO and acetate buffer solution pH 4.2 ± 0.5 with concentration; 1%; 18.66%; 1.92%; 3.42%; up to 100%, respectively. The characteristics of ubiquinone (co-Q10) nanoemulsion were observed in terms of droplet morphology by transmission electron microscope (TEM) and droplet size by particle analyzer, the pH and viscosity value. The ubiquinone (co-Q10) penetration test in the nanoemulsion system was compared with the emulsion on the rat skin. Result of this research showed the droplet morphology of ubiquinone (co-Q10) in nanoemulsion was spherical. The droplet size was 93.2 ± 2.78 nm. The pH value was 4.12 ± 0.02, and the viscosity was 8.5 cPas. Penetrasi of ubiquinone (co-Q10) in nanoemulsion was deeper (269 ± 48.12 and 993 ± 36.49 μm) than in emulsion (26.33 ± 6.43 and 110.33 ± 9.124 μm), after 2 and 6 hours sample application.

Item Type: Article
Uncontrolled Keywords: Nanoemulsion, Skin Penetration, Ubiquinone (co-Q10), Virgin Coconut Oil (VCO).
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Tristiana Erawati, NIDN. 0018055803UNSPECIFIED
Widji Soeratri, NIDN. 0006105103UNSPECIFIED
Noorma Rosita, NIDN. 0025126506UNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 11 Oct 2019 08:33
Last Modified: 11 Oct 2019 08:33
URI: http://repository.unair.ac.id/id/eprint/87915
Sosial Share:

Actions (login required)

View Item View Item