Characteristics and Stability of Nanostructured Lipid Carrier (NLC) Aleurites Moluccana Seed Oil (AMS oil) Using Various Combinations of Beeswax and Oleum Cacao

Tristiana Erawati, NIDN. 0018055803 and Denara Asha Putri and Arum Sekar Maharani and Noorma Rosita, NIDN. 0025126506 and Widji Soeratri, NIDN. 0006105103 (2019) Characteristics and Stability of Nanostructured Lipid Carrier (NLC) Aleurites Moluccana Seed Oil (AMS oil) Using Various Combinations of Beeswax and Oleum Cacao. International Journal of Drug Delivery Technology, 9 (1). pp. 94-97. ISSN 0975-4415

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Abstract

This study aims to determine the effect of the combination of beeswax and oleum cacao on the characteristics and stability of nanostructured lipid carrier-aleurites moluccana seed oil (NLC-AMs oil). The combination ratio of beeswax-oleum cacao and AMs oil is 3:1 which total lipid 20%, while the ratio of beeswax-oleum cacao used were F1(100:0); F2 (50:50); F3 (25:75); and F4 (0:100). These preparations are made by the high shear homogenization method because the processing technique is relatively easier, faster and it is possible to get nanoparticle size. Then characterization and physical stability test (real time, thermal cycling test, and centrifugation) were carried out. The results of this study can be concluded that: 1) NLC-AMs oil with combinations of beeswax and oleum cacao has smaller particle size than those using only single solid lipids (oleum cacao or beeswax). 2) Increased concentration of oleum cacao in the NLC-AMs oil system increases its viscosity. 3) The ratio of beeswax and oleum cacao affects the recrystallization index of the NLC-AMs oil. The lowest recrystallization index is in the NLC-AMs oil with a combination of beeswax-oleum cacao in F2 (50:50). 4) The results of the real time stability test for 8 weeks of storage revealed the NLC-AMs oil system with a combination of solid fat beeswax and oleum cacao on F3 (25:75) had the best stability. 5) All formulas are not stable against extreme temperature changes (thermal cycling test) and shocks (centrifugation) indicated by system separation.

Item Type: Article
Uncontrolled Keywords: Aleurites moluccana seed oil (AMs oil), Beeswax, Nanostructured lipid carrier (NLC), Oleum cacao.
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Tristiana Erawati, NIDN. 0018055803UNSPECIFIED
Denara Asha PutriUNSPECIFIED
Arum Sekar MaharaniUNSPECIFIED
Noorma Rosita, NIDN. 0025126506UNSPECIFIED
Widji Soeratri, NIDN. 0006105103UNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 14 Oct 2019 02:51
Last Modified: 14 Oct 2019 02:51
URI: http://repository.unair.ac.id/id/eprint/87954
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