Characterisation Of Solid Lipid Nanoparticles P-Methoxycinnamic Acid (SLN-PMCA) Formulated With Different Lipid Component: Stearic Acid And Cetyl Alcohol

Tegar Gusta Rahmawan and Noorma Rosita, NIDN. 0025126506 and Tristiana Erawati, NIDN. 0018055803 (2012) Characterisation Of Solid Lipid Nanoparticles P-Methoxycinnamic Acid (SLN-PMCA) Formulated With Different Lipid Component: Stearic Acid And Cetyl Alcohol. PharmaScientia, 1 (1). pp. 23-29. ISSN 2302-0725

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Abstract

Solid lipid nanoparticles (SLN) had been increasingly investigated as a new drug delivery system. SLN had several benefits as a topical drug carrier. p-Methoxycinnamic acid (PMCA) was a hidrolized product of ethyl-p-methoxycinnamic (EPMC), which is the highest component of Kaempferia Galanga extract, was proposed to have an antinociceptive activity. The aim of this study is to identify the characteristics of SLN-PMCA formulated through different lipid matrices, such as stearic acid and cetyl alcohol. SLN was prepared using high shear homogenization method at 25000 rpm for 8 minutes. The previous observed formula (Misra, et al, 2004) was used as the reference formula with few modifications. SLN-PMCA product were characterized for entrapment efficiency, morphology and particle sized. The result showed cetyl alcohol had higher entrapment efficiency (mean 68,54%) and smaller particle size (mean 119,25 nm) than stearic acid contained formula. The Transmission Electron Microscope (TEM) result showed spherical particles for cetyl alcohol while stearic acid was oval-shaped.

Item Type: Article
Uncontrolled Keywords: p-Methoxycinnamic acid, Solid lipid nanoparticles, Cetyl alcohol, Stearic acid, High shear homogenization
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Tegar Gusta RahmawanUNSPECIFIED
Noorma Rosita, NIDN. 0025126506UNSPECIFIED
Tristiana Erawati, NIDN. 0018055803UNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 10 Oct 2019 02:26
Last Modified: 10 Oct 2019 02:26
URI: http://repository.unair.ac.id/id/eprint/88080
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