Comparison of Anti Bacterial Efficacy of Photodynamic Therapy and Doxycycline on Aggregatibacter Actinomycetemcomitans.

Erni Maduratna Setiawati and Vina Puji Lestari and Suryani Dyah Astuti, NIDN. 0008046902 (2018) Comparison of Anti Bacterial Efficacy of Photodynamic Therapy and Doxycycline on Aggregatibacter Actinomycetemcomitans. African Journal of Infectious Diseases, 12 (1S). pp. 95-103. ISSN 2006-0165

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Official URL: https://journals.athmsi.org/index.php/AJID/article...

Abstract

Background: Aggregatibacter actinomycetemcomitans (A.actinomycetemcomitans) is an anaerobic bacterium has been frequently associated with aggressive periodontitis. Photodynamic therapy (PDT) is a medical treatment to prevent infection progression that utilizes light to activate a photosensitizing agent. Doxycycline is an antibacterial having photosensitivity. This study aimed to evaluate potential doxycycline as an antibacterial and photosensitizer combine PDT against A.actinomycetemcomitans bacteria. Material and methods: Samples were distributed to 4 groups as follow: (1) Groups A treated with a diode laser, (2) Group B treated with doxycycline 0,1% and laser, (3) Group C treated only with Doxycycline 0.1%, and (4) Group D no exposure doxycycline/laser. Data were analyzed by one-way ANOVA and Tukey's HSD test at 5% significance level. Results: In this study, doxycycline 0.1% has the effect of reducing the bacterial viability of (59.60±3.26%). Whereas laser exposure 120 s combined with doxycycline produce the effect of bacterial viability reduction (88.50±2.83%) is not significantly different from the effect of laser 120 s exposure (88.79±2.60%). In clinical treatment, the application of laser exposure is generally at the duration of the exposure time of 30 s. The results of this study indicate that the duration of laser exposure 30 s shows a reduction in bacterial viability (44.91±1.69%) equal to the laser and with a combination of doxycycline and laser exposure (70.70±2.43%). So at low doses of laser exposure, doxycycline 0.1% combined with the laser results in the greatest reduction in bacterial viability, significantly different from laser exposure alone. Conclusion: at low doses of laser exposure (30s with energy 3.68 J/cm 2 ), doxycycline 0.1% combined with the laser results in the greatest reduction in bacterial viability, significantly different with laser exposure alone.

Item Type: Article
Uncontrolled Keywords: Photodynamic therapy, doxycycline, Aggregatibacter actinomycetemcomitans
Subjects: Q Science > Q Science (General)
Divisions: 08. Fakultas Sains dan Teknologi > Fisika
Creators:
CreatorsEmail
Erni Maduratna SetiawatiUNSPECIFIED
Vina Puji LestariUNSPECIFIED
Suryani Dyah Astuti, NIDN. 0008046902UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 03 Oct 2019 03:07
Last Modified: 03 Oct 2019 03:07
URI: http://repository.unair.ac.id/id/eprint/88101
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