HUMAIRAH, NIM011511133044 (2019) PREVALENSI Klebsiella pneumoniae DAN Escherichia coli YANG RESISTEN TERHADAP KARBAPENEM DI RSUD DR. SOETOMO SURABAYA. Skripsi thesis, Universitas Airlangga.

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Abstract

Background: Antibiotic resistance is the most urgent global problem, especially resistance to carbapenem in Klebsiella pneumonia and Escherichia coli. Infection caused by antibiotic-resistant bacteria is very difficult to treat, so the spread of carbapenem resistance continues to expand and causes high morbidity and mortality. Purpose: To determine the prevalence of Klebsiella pneumonia and Escherichia coli that are resistant to carbapenem at Dr. Soetomo General Hospital, Surabaya. Method: This research is a descriptive type using secondary data taken from the logbook in Clinical Microbiology Installation at Dr. Soetomo General Hospital. Results: From 1026 isolates, there are 300 Klebsiella pneumonia isolates (71%) and 726 Escherichia coli isolates (29%). The highest prevalence of Klebsiella pneumonia which is resistant to carbapenem is (12%) 37/300 isolates in ertapenem and Escherichia coli of (4%) 33/726 isolates to ertapenem. Based on age groups, the highest prevalence of carbapenem-resistant Klebsiella pneumonia of (16%) 3/19 against imipenem and ertapenem in adolescents. Escherichia coli is (7%) 4/61 against meropenem in children. Based on the health service, Klebsiella pneumonia (75%) 6/8 isolates on meropenem in the obgyn unit and on Escherichia coli with (14%) 2/14 in ICU on meropenem and ertapenem. Conclusion: The prevalence of Klebsiella pneumonia which is resistant to carbapenem is higher compared to Escherichia coli. The prevalence of resistance to ertapenem is higher than other types of carbapenem. Based on age groups, the prevalence of carbapenem resistance in Klebsiella pneumonia is higher in adolescence and Escherichia coli was higher in children. Based on health service, the highest prevalence of carbapenem resistance in Klebsiella pneumonia is in the obgyn unit and Escherichia coli in the ICU.

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