Macrophages Analysis on Gingival Tissue of Diabetic Rats after Insulin Leaf Extract Administration

Tuti Kusumaningsih, NIDN. 0023105202 and Muhammad Luthfi, NIDN. 0623108301 and Marsecall Dhira Brata Moffan, NIM. 021311133165 (2018) Macrophages Analysis on Gingival Tissue of Diabetic Rats after Insulin Leaf Extract Administration. Journal of International Dental and Medical Research, 11 (1). pp. 308-311. ISSN 1309-100X

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Abstract

Periodontitis is an infection of periodontal tissue which generally commonly associated with diabetes mellitus. A. actinomycetemcomitans is a major cause of aggressive periodontitis. Macrophages and monocytes are increased in inflammation caused by bacteria. Macrophages are involved in the process of phagocytosis. Insulin leaf(Smallanthus sonchifolia) contains anti-diabetic and anti-microbial activities that can inhibit or kill bacteria. To determine the effect of insulin leaf extract to decrease the number of macrophages in the gingival tissues of diabetic rats that induced A. actinomycetemcomitans. This study was laboratory experimental with post-test only. Samples were divided into two groups;treatment group and control group. The control group rats were given alloxan and A. actinomycetemcomitans, while experimental group were given alloxan, A. actinomycetemcomitans, and the insulin leaf extract. Examination of macrophages is done by making histological preparations with Hematoxin-eosin staining. The mean of number of macophages in control group was 6.04 ± 2.133, while in the treatment group was 2.62 ± 0.517. Statistical analytic using Paired T test showed a significant decrease of the number of macrophages (p<0.049). There was a decrease in the number of macrophages in the gingival tissues of diabetic rats induced by A. actinomycetemcomitans after giving insulin leaf extract.

Item Type: Article
Uncontrolled Keywords: Extract of insulin leaf, diabetes mellitus, periodontitis, macrophage
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Oral Biology
Creators:
CreatorsNIM/NIDN
Tuti Kusumaningsih, NIDN. 0023105202UNSPECIFIED
Muhammad Luthfi, NIDN. 0623108301UNSPECIFIED
Marsecall Dhira Brata Moffan, NIM. 021311133165UNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 22 Oct 2019 06:16
Last Modified: 22 Oct 2019 06:30
URI: http://repository.unair.ac.id/id/eprint/89277
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