Toxicity test-n-Hexano : Ethyl A cetate (3:7) Fraction of Sudarmala (Artemesia Vulgaris L.)

Ira Arundina, NIDN. 0028107102 and Theresia Indah Budhy S., NIDN. 0007066104 and Intan Nirwana, NIDN. 0030045702 and Retno Indrawati, NIDN. 0012115903 and Muhammad Luthfi, NIDN. 0623108301 (2016) Toxicity test-n-Hexano : Ethyl A cetate (3:7) Fraction of Sudarmala (Artemesia Vulgaris L.). In: Procedia Chemistry. Elsevier, pp. 174-178. ISBN 00002009

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Sudamala (Artemisia vulgaris L.) is commonly used in the community as anti-tumor in digestive organ, including in oral cavity. However, there have been no scientific studies about oral anti-carcinogenic active substances of Sudamala. The purpose of this study was to analyse the effect of per oral administration of n-hexane : ethyl acetate (3:7) fraction of Artemisia vulgaris L. on healthy mice. This experimental study used male Swiss Webster (Balb C) strain mice (Mus musculus) 2.5 months old, 20-30 grams by weight. Group 1, the mice received 0.5% CMC- Na fraction solvent, as a control. Group 2, the mice received 200 mg/kgbw n-hexane : ethyl acetate (3:7) fraction of Sudamala (Artemisia vulgaris L). The fraction was given once daily for 8 weeks per oral according to the mice's weight. At the end of 8th week, the mice were killed and oral mucosal tissue was taken for biopsy specimens. Tunnel assay for Apoptosis and immunohistochemistry were undertaken for PCNA. T test analysis showed there was no significant difference between control and treatment groups. The fractions of n-hexane : ethyl acetate (3:7) of Sudamala (Artemisia vulgaris L) was not toxic , it was not harmful to living tissue in healthy mice.

Item Type: Book Section
Uncontrolled Keywords: ethyl acetate fraction; Artemisia vulgaris L.; toxicity
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Oral Biology
Ira Arundina, NIDN. 0028107102UNSPECIFIED
Theresia Indah Budhy S., NIDN. 0007066104UNSPECIFIED
Intan Nirwana, NIDN. 0030045702UNSPECIFIED
Retno Indrawati, NIDN. 0012115903UNSPECIFIED
Muhammad Luthfi, NIDN. 0623108301UNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 22 Oct 2019 06:35
Last Modified: 22 Oct 2019 06:35
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