The expression of pulpal substance P after dentinal application of Escherichia coli lipopolysaccharide

Kun Ismiyatin, NIDN. 0002046001 and Soegeng Wahluyo, NIDN. 0010115405 and Adioro Soetojo, NIDN0010085102 and Retno Pudji Rahayu, NIDN. 0014115906 and Haryono Utomo and Cinitra Anindya, NIM. 020911124 (2018) The expression of pulpal substance P after dentinal application of Escherichia coli lipopolysaccharide. Saudi Endodontic Journal, 9 (3). pp. 169-172. ISSN 23201495

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Purpose: The purpose of the research was to quantify the expressions of substance P (SP) in sensory nerve cells contained in the dental pulp of Wistar rats following the application of Escherichia coli lipopolysaccharide (LPS). Materials and Methods: Forty‑two male Wistar rats were divided into six groups (n = 7): Groups C1 and C2 received no treatment and served as negative controls; Groups C3 and C4 only had cavity preparation; and Groups T1 and T2 received cavity preparation and treated with LPS. All teeth were subjected to immunohistochemistry analysis of SP expression at 24 h (C1, C3, and T1) and at 72 h (C2, C4, and T2). Results: There was a significant increase in the SP of the T1 group compared to the C1 and C3 groups and of the T2 group compared to the C2 and C4 groups. While there was no significant difference in the expression of SP between the C1 and C2 groups, a significant increase was found in T1 group compared to that of the T2 group and in the C3 group compared to the C4 group (P < 0.05). Conclusion: The application of LPS to teeth resulted in the highest expression of SP after 24 h which then decreased after 72 h.

Item Type: Article
Uncontrolled Keywords: Lipopolysaccharides, pulpitis, sensory neurons, substance P, Wistar rats
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Oral Biology
Kun Ismiyatin, NIDN. 0002046001UNSPECIFIED
Soegeng Wahluyo, NIDN. 0010115405UNSPECIFIED
Adioro Soetojo, NIDN0010085102UNSPECIFIED
Retno Pudji Rahayu, NIDN. 0014115906UNSPECIFIED
Cinitra Anindya, NIM. 020911124UNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 17 Oct 2019 04:41
Last Modified: 17 Oct 2019 04:41
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