NIKE PULIANSARI, 050710076 (2012) SKRINING AKTIVITAS ANTIMALARIA IN VITRO EKSTRAK ETANOL 80% TANAMAN STROPHACANTHUS MEMBRANIFOLIUS, STROBILANTHES INVOLUCRATA, GOMPHOSTEMMA JAVANICUM, PIPER SP., DAN PSYCHOTRIA SP. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Indonesia is known in biodiversity rich of the plants species of which only a small proportion of the species have been investigated in detail. This research was carried out to investigate the antimalarial activity of five plants from the Cangar forest in East Java. The 80% ethanol extract of Strophacanthus membranifolius, Strobilanthes involucrata, Gomphostemma javanicum, Piper sp, and Psychotria sp. has been tested for their in vitro antimalarial activity against Plasmodium falciparum 3D7. The result showed that ethanol extract of Piper sp.was the most active as antimalarial with IC 50 0.207 g/mL whereas the Strophacanthus membranifolius, Strobilanthes involucrata, and Gomphostemma javanicum were active as antimalarial with IC50 value 3.498 g/mL, 1.268 g/mL and 1.454 g/mL. Respectively 80% ethanol extract of Psychotria sp. was inactive as antimalarial due to high value of IC50 that is 381.646 g/mL.

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