POTENSI ANTIJAMUR ISOLAT Streptomyces spp. DARI TANAH KOMPOS RKBS TERHADAP Trichophyton sp.

MEGA FERDINA WARSITO, 050710267 (2012) POTENSI ANTIJAMUR ISOLAT Streptomyces spp. DARI TANAH KOMPOS RKBS TERHADAP Trichophyton sp. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Trichophyton sp., one of the most prevalent dermatophytes which causes keratin tissue infection, has been widely recognized to be resistant to certain antifungal drugs. Yulistyani et al.(2010) successfuly isolated six isolates of Streptomyces sp.from RKBS which has proven to have antifungal potency against Candida albicans. The potency of those isolates was examined against Trichophyton sp.This study was aimed to investigate the antifungal potency of Streptomyces spp. against Trichophyton sp. Screening method using hole diffusion was employed to reveal whether the isolates could have such antifungal potency. The most active isolate was further observed to figure out the antifungal production profile and the growth profile of Streptomyces in 24 hours period for 12 days. The fermentation was done in ISP-4 medium (pH 7,2 ± 0,2, 150 rpm, and 34,0 ± 1,0 °C). The growth of Streptomyces was measured by dry cell weight method.Based on the screening result, the Streptomyces sp.C,Ep,and F show antifungal potency against Trichophyton sp. which were expressed as inhibition zone. Streptomyces sp.Ep has the highest antifungal potency. It is also find that the antifungal potency of Streptomyces sp.Ep reaches its peak of antifungal production in the fourth day of fermentation.The potency of Streptomyces sp. Ep against Trichophyton sp.was determined by three level dose method using ketoconazole as reference drugThe antifungal potency of 100 μl Streptomyces sp. Ep suspension is equivalent to 8.325 ppm ketokonazol.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK 2 FF 397 11 War p
Uncontrolled Keywords: A.Toto Poernomo,spp
Subjects: Q Science
Q Science > QD Chemistry
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
MEGA FERDINA WARSITO, 050710267UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorA. Toto Poernomo, Drs.Apt.,MSiUNSPECIFIED
Depositing User: Mr Mudjiono Mudj
Date Deposited: 06 Feb 2012 12:00
Last Modified: 15 Aug 2016 08:17
URI: http://repository.unair.ac.id/id/eprint/9014
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