MADE RATIH PARAMITASARI, 050810115 (2012) PROFIL PENGGUNAAN ANTIMIKROBA PADA PENDERITA LEUKEMIA LIMFOBLASTIK AKUT DENGAN DEMAM NEUTROPENIA ( Studi di Instalasi Rawat Inap (IRNA) Anak RSUD Dr. Soetomo Surabaya ). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Febrile neutropenia is a neutropenic condition with absolute neutrophil count <500/mm3 and fever with body themperature ≥380C. Fever neutropenia is commonly occurs in patient with acute lymphoblastic leukemia (ALL) because of failed hemopoesis proccess in ALL patient and chemoteraphy that undertaken by patient. Febrile neutropenia should be treated immediately to cured bacteremia condition and prevent severe infection. The aim of this study were to descibe the antimicrobial profile in acute lymphoblastic leukemia patient with febrile neutropenia, including type of antimicrobial drug, dosage, route of administration, time and duration of antimicrobial drug use and to identify actual and potential Drug Related Problems (DRPs). This study was a retrospective study by using descriptive analysis in acute lymphoblastic leukemia patient with febrile neutropenia at Department of Child Health Dr. Soetomo Hospital Surabaya on period January 1st until December 31st 2011 (N=31). The result showed that most common used antimicrobial drug were ampicillin-sulbactam, meropenem, flukonazol. Other antimicrobial drug that also used in patient therapy were gentamycin, metronidazol, erythromycin, clindamycin, and cloxacilin. Doses and frequency were appropriate to literature. The potential drug related problems were the adverse drug reaction of ciprofloxacin (3%) and aminoglycoside (10%) and actual and the actual drug related problem were empiric antimicrobial use in too long therm (>10 days) (42%).

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