ANGGRAHAYU RIZKY SETYARULI, 050810030 (2012) PROFIL PENGGUNAAN INSULIN KERJA MENENGAH DAN KERJA PANJANG PADA PASIEN DIABETES MELLITUS (Studi dilaksanakan di Instalasi Rawat Inap Ilmu Penyakit Dalam RSUD Dr. Soetomo). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of this study was to identify utilization profile of intermediate-acting and long-acting insulin in hospitalized diabetes mellitus patients in Dr.Soetomo general hospital Surabaya and problem related to the use of insulin. The study was conducted prospectively from March- May 2012. The inclusion criteria was diabetes mellitus patient, type I or type II with or without complication who received intermediate-acting or long-acting insulin, with complete medical record. The result showed that from 55 patients, most of them in the range of age 45-64 y.o (74.55%). The most complication and comorbid was foot ulcer (56.36%) and urinary tract infection (32.73%). Condition of infections occured in most patients with diabetes mellitus (74.55%) that could influence blood glucose control. The type of intermediate-acting insulin used was Humulin N (18.18%) whereas long-acting insulin was detemir (61.82%) and glargine (20.00%). Long-acting insulin was preferred than intermediate-acting insulin related to secretion of long-acting insulin closely mimic secretion insulin physiologic and the lower risk of nocturnal hypoglycaemia. The initial and maintenance dose of intermediate-acting and long-acting insulin could be varied due to FPG/ random blood glucose and patient’s condition. The incidence of DRPs identified in this study were side effects from the use of insulin i.e. hypoglycaemia (1.82%) and hypokalemia (3.64%), interaction between insulin with other drugs, and alteration dose of insulin without record blood glucose (10.00%).

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