Effectiveness of Rat Bone Marrow Stem Cell Therapy to Rattus novergicus by Teratogenic Model of Particulate Matter on Expression of Kappa Beta (NFKẞ) Nuclear Factor on Placenta

Sri Pantja Madyawati, NIDN. 0010026308 and Widjiati, NIDN. 0015046204 and Rimayanti, NIDN. 0003126305 (2014) Effectiveness of Rat Bone Marrow Stem Cell Therapy to Rattus novergicus by Teratogenic Model of Particulate Matter on Expression of Kappa Beta (NFKẞ) Nuclear Factor on Placenta. In: The 3 Joint International Meetings 2014. Faculty Of Veterinary Medicine, Bogor Agricultural University, Bogor, pp. 102-103. ISBN 978-602-95733-3-6

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Abstract

Air pollution in several cities in East Java has exceeded the threshold set by the government. One of the pollutant components that pollute the air Is particulate matter (PM) [1]. PM component effects health because it is cytotoxic and teratogenic. Particulate Matter can cause nílammation on the respiratory and cardiovascular systems, and it can pass through the placental barrier so that It can affect fetal development. Exposure to Particulate Matter (PM) can affect prenatal maternal health through a variety of mechanisms, including increased Reactive Oxygen Species (ROS), which stimulates macrophages to secrete cytokines TNF-a and NFkB which will further accelerate the process of apoptosis in placenta. Currently, interest In stem cells for the treatment of various diseases Is Increasing. The MarrowStem Bone Cell is utilized for therapy because It has a self-renewing properties, so that therapy need not be repeated. In an teratogenic case, Bone Marrow Stern Cell administration can reduce the inflammation, apoptosis and congenital abnormalities. Therefore, the utilization of Bone Marrow Stem Cell for therapy in the teratogenic case requires a biomolecular repoduction study to reveal the mechanisms of disorders in placentatlon during pregnancy as a basis of proving the study scientifically. This study used rats as an animal model of teratogenic particulate matter merely for ethical consideration and smooth execution of the study.

Item Type: Book Section
Subjects: S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals
S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > SF811-909 Veterinary medicine of special organs, regions, and systems
Divisions: 06. Fakultas Kedokteran Hewan > Reproduksi Veteriner
Creators:
CreatorsNIM/NIDN
Sri Pantja Madyawati, NIDN. 0010026308UNSPECIFIED
Widjiati, NIDN. 0015046204UNSPECIFIED
Rimayanti, NIDN. 0003126305UNSPECIFIED
Depositing User: Nn Erna Dwi Indriyani
Date Deposited: 25 Nov 2019 01:58
Last Modified: 25 Nov 2019 01:58
URI: http://repository.unair.ac.id/id/eprint/90452
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