Nopriadi Nelintong and Isnaeni and Noor Erma Nasution (2015) Aktivitas Antibakteri Susu Probiotik Lactobacilli Terhadap Bakteri Penyebab Diare (Escherichia coli, Salmonella typhimurium, Vibrio cholerae). Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2 (1). pp. 25-30. ISSN 2406-9388

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Abstract

Lactobacillus plantarum, Lactobacillus casei, and Lactobacillus acidophilus fermented milk were made in single and mixed preparation. Their antibacterial activities were investigated against diarrhea’s bacterial Escherichia coli, Salmonella typhimurium, Vibrio cholera as bacterial test and cyprofloxacine as reference standard by using agar diffusion method. The highest zone of inhibitions produced by L. plantarum and L. casei fermented milk at 9:1 ratio, 12,33 ± 0,07 mm, 12,43 ± 0,29 mm, and 12,32 ± 0,81 mm against Escherichia coli, Salmonella typhimurium, and Vibrio cholera respectively. The highest activity of the combination of L. plantarum and L. casei (9:1) and L. acidophilus was produced at 9:1 ratio, 13,08±0,08 mm, 13,46±0,04 mm, and 13,21±0,02 mm against Escherichia coli, Salmonella typhimurium, and Vibrio cholera respectively. Minimum inhibitory concentration of the combination fermented milk with L. plantarum and L. casei (9:1) and L. acidophilus in ratio 9:1 was 40% against Escherichia coli, Salmonella typhimurium, and Vibrio cholerae.

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