KARAKTERISASI KOMPLEKS INKLUSI ASAM p-METOKSISINAMAT- β-SIKLODEKSTRIN (Dibuat dengan Metode Co-grinding)

YUNA FAJAR HERDIANSYAH, 051511133046 (2019) KARAKTERISASI KOMPLEKS INKLUSI ASAM p-METOKSISINAMAT- β-SIKLODEKSTRIN (Dibuat dengan Metode Co-grinding). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Para-methoxycinnamic acid (pMCA) is a substance hydrolized from ethyl p-methoxycinnamate which is a major substance isolated from Kaempferia galanga L. pMCA has an analgesic effect, but it has a very low solubility in water (0.712 mg/ml). Therefore, to improve the solubility of pMCA, it was complexed with β-cyclodextrin (βCD). The purpose of this study was to characterize pMCA-βCD inclusion complex prepared in 1:1 molar ratio by co-grinding method. The inclusion complex was characterized by Differential Thermal Analysis (DTA), Powder X-Ray Diffractometer (PXRD), Fourier Transform Infrared Spectroscopy (FTIR), then compared to non-grinded pMCA, grinded pMCA, non-grinded βCD, grinded βCD, non-grinded physical mixture, and grinded physical mixture. The DTA study showed the intensity of endothermic peak was decreased and shifted to different temperature. The diffractogram of pMCA-βCD inclusion complex showed the decresion of the pMCA peak lines. The FTIR spectra showed that absorption band of carboxyl and alkene group from the pMCA were loss, and its aromatic group was shifted. The inclusion complex is shown to have different characteristics when compared with non-grinded pMCA, grinded pMCA, non-grinded βCD, grinded βCD, non-grinded physical mixture, and grinded physical mixture. These changing of characteristics proved that inclusion complex was formed.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F 23/19 Her k
Uncontrolled Keywords: p-methoxycinnamic acid, β-cyclodextrin, inclusion complex, co-grinding method, characterization
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
YUNA FAJAR HERDIANSYAH, 051511133046UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDr. Dewi Isadiartuti, M.Si., Apt., NIDN: '0020056509UNSPECIFIED
Depositing User: Dwi Marina
Date Deposited: 11 Nov 2019 03:01
Last Modified: 11 Nov 2019 03:01
URI: http://repository.unair.ac.id/id/eprint/90654
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