PENGARUH SISTEM DISPERSI PADAT ANDROGRAFOLIDA- KARBOKSIMETIL KITOSAN TERHADAP BIOAVAILABILITAS ANDROGRAFOLIDA

DWI WULAN ANDARINI, 051511133038 (2019) PENGARUH SISTEM DISPERSI PADAT ANDROGRAFOLIDA- KARBOKSIMETIL KITOSAN TERHADAP BIOAVAILABILITAS ANDROGRAFOLIDA. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Andrographolide (ADG) a diterpene lactone substance from (Andrographis paniculata Nees) has pharmacological activities like hepatoprotective, anticancer, anti-inflammatory, antiviral and anti-malarial. Andrographolide has a low aqueous solubility and low bioavailability after oral administration. Andrographolide-carboxymetyl chitosan solid dispersion system (SDS ADG-CMCS) can be used to improve the solubility and dissolution of andrographolide.The aim of the study was determine the bioavailability (parameter AUC) of SDS ADG-CMCS. SDS ADG-CMCS prepared by solubilitation and spray drying method. Bioavailability test is performed using New Zealand male rabbits divided into three treatment group: ADG, SDS ADG-CMCS, and physical mixture ADG-CMCS. Rabbits are given treatment by oral using sonde and blood samples are taken at specified interval time during 3 hours. ADG concentration in blood samples are prepared and determined using HPLC. The result of bioavailability test (parameter AUC0−180) SDS ADG-CMCS increased 4.3 times compared to andrographolide substance and the result of One way ANOVA (α= 0,05) is bioavailability (AUC0−180) of SDS ADG-CMCS significantly increased compared bioavailability of andrographolide.

Item Type: Thesis (Skripsi)
Additional Information: KKB K-2 FF.F 39/19 And p
Uncontrolled Keywords: andrographolide, carboxymethyl chitosan, solid dispersion system, bioavailability
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
DWI WULAN ANDARINI, 051511133038UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDr. Retno Sari, M.Sc, Apt, NIDN: '0008106303UNSPECIFIED
Depositing User: Dwi Marina
Date Deposited: 11 Nov 2019 04:42
Last Modified: 11 Nov 2019 04:42
URI: http://repository.unair.ac.id/id/eprint/90670
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