AKTIVITAS ANTIVIRAL EKSTRAK RIMPANG Curcuma domestica Val. DAN Curcuma xanthorrhiza Roxb. TERHADAP VIRUS HEPATITIS C SECARA IN VITRO

AN NISA NUR LAILA, 051511133020 (2019) AKTIVITAS ANTIVIRAL EKSTRAK RIMPANG Curcuma domestica Val. DAN Curcuma xanthorrhiza Roxb. TERHADAP VIRUS HEPATITIS C SECARA IN VITRO. Skripsi thesis, Universitas Airlangga.

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Abstract

Hepatitis C is a liver disease caused by the hepatitis C virus (HCV). It is estimated that 3 million Indonesians suffer from Hepatitis C. The latest HCV treatment has provided high cure rate with SVR more than 90%, using a combination of DAA (Direct Acting Antiviral). However, those treatment possessed a high cost and a side effects. Medicinal plants are potential sources to find alternative medicine for HCV. The purpose of this study is to determine antiviral activity from Curcuma domestica and Curcuma xanthorrhiza rhizome extract against HCV. Both of them have been reported to mediate many biopharmacological activity, C. domestica and C xanthorrhiza contain a curcumin substance which has been know to inhibit the entry step of HCV. The rhizome extract was inoculated to HuH7it cell culture to determine the activity, toxicity, and the target of the extract in the HCV life cycle. From anti-HCV activity test, it was found that extract of C. domestica and C. xanthorrhiza inhibit HCV with IC50 value were 4.59±0.54 μg/ml and 14.35±0.28 μg/ml, respectively. In the toxicity test, the CC50 value of C. domestica extract and C. xanthorrhiza extract were 93.14±0.014 μg/ml and 153.26±11.13 μg/ml, respectively.The mode of action analysis was revealed that both C. domestica and C. xanthorrhiza extract inhibit HCV infection in the entry and post entry step, while in C. xanthorrhiza acted dominantly in the entry step. Those results suggested that C. domestica and C. xanthorrhiza may a good candidate for anti-HCV agent.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FT 14/19 Lai a
Uncontrolled Keywords: antihepatitis C virus, C. domestica, C. xanthorrhiza, hepatitis C virus
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM/NIDN
AN NISA NUR LAILA, 051511133020UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDr. Aty Widyawaruyanti, M.Si., Apt., NIDN :'0026046210UNSPECIFIED
Depositing User: Dwi Marina
Date Deposited: 12 Nov 2019 07:45
Last Modified: 12 Nov 2019 07:45
URI: http://repository.unair.ac.id/id/eprint/90723
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