SAFAATUL LAYSA, 051511133149 (2019) AKTIVITAS ANTIVIRUS EKSTRAK ETANOL RIMPANG Zingiber officinale Rosc. DAN Curcuma heyneana Val & Zijp. TERHADAP HEPATITIS C VIRUS SECARA IN VITRO. Skripsi thesis, Universitas Airlangga.

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Abstract

Hepatitis C infection is a global world problem. The cronically infection has infected around 71 million people that caused serious morbidity. Hepatitis C treatment is still limited, due to high treatment costs and some drugs have experienced resistance. Therefore, the new agent for anti hepatitis C is needed. This study examined antihepatitis C activity from ethanol extract of Z. officinale rhizome Sand C. heyneana by in vitro culture cells. Both of them possessed a potential antihepatitis C virus activities with the IC50 values of 0.16±0.89 μg/mL and 0.19±1.23 μg/mL, respectively, without any toxicity effect, the CC50 of Z. officinale was 61.73 μg/mL and C. heyneana was 147.04 μg/mL. The target mechanism of extract were found that ethanol extract of Z. officinale rhizome inhibit at the post-entry step of hepatitis C virus life cycle, while ethanol extract of C. heyneana rhizome inhibit at the entry and post-entry step. These results indicated that Z. officinale and C. heyneana may potential to be developed for antihepatitis C agents.

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