AKTIVITAS ANTIINFLAMASI NATRIUM DIKLOFENAK DALAM SISTEM NIOSOM SPAN 20 DAN SPAN 60 (Sistem Niosom Natrium Diklofenak – Span – Kolesterol (1:6:6))

YOSINTA SAFITRI, 050810209 (2012) AKTIVITAS ANTIINFLAMASI NATRIUM DIKLOFENAK DALAM SISTEM NIOSOM SPAN 20 DAN SPAN 60 (Sistem Niosom Natrium Diklofenak – Span – Kolesterol (1:6:6)). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Diclofenac sodium is usually used in the long therapy of rheumatoid arthitis. Diclofenac sodium has antiinflamation, analgesic and antipiretic activity. Diclofenac sodium is formulated in topical dosage form to avoid the side effect from oral, intramuscular and suppository dosage form. The partition coefficient of diclofenac sodium is 13.4, so it tends to be lipophilic and solubility of diclofenac sodium in water is too small. The amount of diclofenac sodium molecules that can penetrate to stratum corneum is low, so the permeability of skin is low and the penetration diclofenac sodium is not optimal. Therefore, diclofenac sodium is formulated in niosomes system to increase the bioavailability. This research is to observe the antiinflamatory activity of niosomes system and compositions of niosomes system are; diclofenac sodium : Span 20 : cholesterol (1:6:6) and diclofenac sodium : Span 60 : cholesterol (1:6:6) by Carragenan induced hind paw edema on Wistar rats. The evaluation consists of organoleptic test (form, color and odor), pH, morphologic test (Scanning Electron Microscopy) and drug entrapment efficiency and antiinflamatory activity.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F.03/13 Saf a
Uncontrolled Keywords: DICLOFENAC SODIUM, ANTIINFLATORY, NIOSOMES, SPAN 20
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsNIM/NIDN
YOSINTA SAFITRI, 050810209UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTutiek Purwanti, Dra., Apt., M.Si.UNSPECIFIED
Depositing User: mat sjafi'i
Date Deposited: 13 Feb 2013 12:00
Last Modified: 04 Jul 2017 22:11
URI: http://repository.unair.ac.id/id/eprint/9078
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