PENETRASI NATRIUM DIKLOFENAK SISTEM NIOSOM SPAN 60 – KOLESTEROL DALAM BASIS GEL HPMC 4000 (Sistem Niosom Natrium Diklofenak – Span 60 – Kolesterol = 1:6:6)

ABDULLOH SUYUTI, 050810017 (2012) PENETRASI NATRIUM DIKLOFENAK SISTEM NIOSOM SPAN 60 – KOLESTEROL DALAM BASIS GEL HPMC 4000 (Sistem Niosom Natrium Diklofenak – Span 60 – Kolesterol = 1:6:6). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The present study was designed to determine characteristics and penetration of diclofenac sodium in niosome system from HPMC 4000 gel bases preparation. The compositions of niosome are diclofenac sodium, Span 60, and cholesterol with molar ratio 1:6:6. There were two formulas in this study. Diclofenac sodium in HPMC 4000 gel without niosome, and HPMC 4000 gel with niosome system. The result showed that niosome system had effect on color and odor. Niosome system also had effect on pH and spread diameter of zero load. Data analyze showed that pH of formula control was (6,29 ± 0,04) and formula test was (6,82 ± 0,02). Spread diameter of zero load for formula control was (5,47 ± 0,06) cm and formula test was (4,90 ± 0,10) cm. Penetration test was carried out with dissolution tester with paddle stir in phosphate buffer saline pH 7,4 ± 0,05, volume 500 mL, temperature 37 ± 0,5 oC, and stirred velocity 100 rpm. The penetration flux was counted from slope of linear regression between time versus the cumulative amount of diclofenac sodium gel. The flux of formula control and formula test were (0,9505 ± 0,0451) μg/cm2/min and (0,6357 ± 0,0747) μg/cm2/min. Membrane permeability for formula control was (9,3075.10-5 ± 4,4449.10-6) cm/min and formula test was (6,3158.10-5 ± 7,4284.10-6) cm/min. The result was analyzed by statistic programmed using independent sample t-test with degree of confident 95% (α = 0,05). Research result revealed that diclofenac sodium penetration from HPMC 4000 gel with niosome system was lower than formula without niosome

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F.05/13 Suy p
Uncontrolled Keywords: DICLOFENAC SODIUM, DRUG PENETRATION
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsEmail
ABDULLOH SUYUTI, 050810017UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorTutiek Purwanti, Dra., Apt., M.SiUNSPECIFIED
Depositing User: mat sjafi'i
Date Deposited: 13 Feb 2013 12:00
Last Modified: 04 Jul 2017 22:45
URI: http://repository.unair.ac.id/id/eprint/9080
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