Thein Myint and Muhammad Miftahussurur and Ratha-korn and New Ni and Than Than Aye and Phawinee Subsmwong and Tomohisa Uchida and Varocha Mahachai and Yaoshio Yamaoka (2018) Characterizing Helicobacter pylori cagA in Myanmar. Gut and Liver, 12 (1). pp. 51-57. ISSN 2005-1212

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Abstract

Background/Aims Differences in the Helicobacter pylori infection rate are not sufficient to clarify the dissimilarity of gastric cancer incidence between Myanmar and its neighboring countries. To better understand this trend, the H. pylori virulence gene cagA was characterized in Myanmar. Methods Glutamate-proline-isoleucine-tyrosine-alanine (EPIYA) patterns and CagA multimerization (CM) motifs of cagA genotypes were examined by performing polymerase chain reactions and DNA sequencing. Results Of 69 tested H. pylori strains, cagA-positive patients had significantly more severe histological scores in their antrum than cagA-negative patients. Sequence analysis revealed that 94.1% of strains had Western-type cagA containing an EPIYA motif (92.6%) or EPIYT motif (6.4%). The intestinal metaplasia scores in the antral of patients infected with the ABC and ABCC types of cagA were significantly higher than those of patients with AB-type cagA. Interestingly, in patients infected with H. pylori, 46.3% of strains with three EPIYA motifs contained two identical Western-typical CM motifs, and these patients showed significantly higher antrum inflammation scores than patients infected with two identical nontypical-CM motif strains (p=0.02). Conclusions In Myanmarese strains, Western-type cagA was predominant. The presence of CM motifs and the proportion of multiple EPIYA-C segments might partially explain the intermediate gastric cancer risk found in Myanmar.

Item Type:	Article
Uncontrolled Keywords:	Helicobacter pylori, cagA, Myanmar
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Thein Myint UNSPECIFIED Muhammad Miftahussurur NIDN0029097909 Ratha-korn UNSPECIFIED New Ni UNSPECIFIED Than Than Aye UNSPECIFIED Phawinee Subsmwong UNSPECIFIED Tomohisa Uchida UNSPECIFIED Varocha Mahachai UNSPECIFIED Yaoshio Yamaoka UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	06 Dec 2019 06:53
Last Modified:	06 Dec 2019 06:53
URI:	http://repository.unair.ac.id/id/eprint/90844
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