Phawinee Subsomwong and Muhammad Miftahussurur and Ratha-korn Vilaichone and Thawee Ratanachu-ek and Rumiko Suzuki and Junko Akada and Tomosiha Uchida and Varocha Mahachai and Yoshio Yamaoka (2017) Helicobacter pylori virulence genes of minor ethnic groups in North Thailand. Gut Pathogens, 9 (56). pp. 1-11. ISSN 1757-4749

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Abstract

Background There are few studies analyzed concurrently the prevalence and genotypes of Helicobacter pylori infection with the ancestor origins from different ethnics, especially with including minority groups. We recruited a total of 289 patients in MaeSot, Thailand (154 Thai, 14 Thai-Chinese, 29 Karen and 92 Hmong ethnics). The virulence genes and genealogy of the strains were determined by PCR-based sequencing. Results Based on culture and histology/immunohistochemistry, the prevalence of H. pylori infection was 54.5% (158/289). Among 152 isolates cultured, the East-Asian-type cagA was predominant genotype among strains from Hmong, Thai-Chinese and Thai (96.0% [48/50], 85.7% [6/7] and 62.7% [47/75], respectively), whilst majority of strains from Karen had Western-type cagA (73.3% [11/15]). Patients infected with the East-Asian-type cagA strains had significantly higher activity and intestinal metaplasia in the antrum and activity in the corpus than those with Western-type cagA (P = 0.024, 0.006 and 0.005, respectively). The multilocus sequencing typing analysis discriminated that most strains from Hmong and Thai-Chinese belonged to hspEAsia (92.0 and 85.7%, respectively), whereas strains from Karen predominantly possessed hpAsia2 (86.7%) and strains from Thai were classified into hspEAsia (45.2%) and hpAsia2 (31.1%). Conclusions Helicobacter pylori genotypes were relatively different among ethnic groups in Thailand and were associated with the source of ancestor even living in a small rural town. Caution and careful check-up are required especially on Hmong ethnic associated with high prevalence of virulence genotypes of H. pylori.

Item Type:	Article
Uncontrolled Keywords:	Helicobacter pylori, Virulence factors, Minor ethnics, North Thailand, Human migration
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Phawinee Subsomwong UNSPECIFIED Muhammad Miftahussurur NIDN0029097909 Ratha-korn Vilaichone UNSPECIFIED Thawee Ratanachu-ek UNSPECIFIED Rumiko Suzuki UNSPECIFIED Junko Akada UNSPECIFIED Tomosiha Uchida UNSPECIFIED Varocha Mahachai UNSPECIFIED Yoshio Yamaoka UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	06 Dec 2019 06:27
Last Modified:	06 Dec 2019 06:27
URI:	http://repository.unair.ac.id/id/eprint/90867
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