PENGARUH KOMPLEKS INKLUSI KURKUMIN-HIDROKSIPROPIL-β-SIKLODEKSTRIN TERHADAP PENINGKATAN LAJU DISOLUSI KURKUMIN (Dibuat dengan Metode Evaporasi)

TIARA PUSPITA DEWI, 050810164 (2012) PENGARUH KOMPLEKS INKLUSI KURKUMIN-HIDROKSIPROPIL-β-SIKLODEKSTRIN TERHADAP PENINGKATAN LAJU DISOLUSI KURKUMIN (Dibuat dengan Metode Evaporasi). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Curcumin is a yellow pigment extracted from Curcuma longa or Curcuma xanthorrhiza. Curcumin has shown various biological activities such as anti inflammation, antioxidant, anti cancer, etc. But its potential is limited by poor bioavailability due to its lack of solubility in aqueous solvents. Hydroxypropyl-β-cyclodextrin has been investigated to increase the solubility and stability of curcumin by the formation of inclusion complex. The purpose of this study was to improve the dissolution rate of poorly soluble curcumin with hydroxypropyl-β-cyclodextrin complexation with ratio of 1:1 by solvent evaporation method. The effect of hydroxypropyl-β-cyclodextrin on the dissolution rate of curcumin was investigated by comparing the dissolution efficiency of curcumin, physical mixture, and curcumin-hydroxypropyl-β-cyclodextrin complex inclusion. The result showed that the dissolution rate of curcumin was improved by the complexation with hydroxypropyl-β-cyclodextrin compared with curcumin and its physical mixture.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F.16/13 Dew p
Uncontrolled Keywords: CURCUMIN, DISSOLUTION RATE, COMPLEX INCLUSION
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
TIARA PUSPITA DEWI, 050810164UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorACHMAD RADJARAM, Dr., Apt.UNSPECIFIED
Depositing User: mat sjafi'i
Date Deposited: 13 Feb 2013 12:00
Last Modified: 02 Sep 2016 03:20
URI: http://repository.unair.ac.id/id/eprint/9091
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