PENGARUH PENGIKAT GELATIN 1% DAN 2% TERHADAP MUTU FISIK DAN DISOLUSI ORALLY DISINTEGRATING TABLET PARASETAMOL DENGAN DISINTEGRAN POLYPLASDON XL-10 5% (Dibuat dengan Basis Manitol dan Metode Freeze Drying)

ARFIAN ARIANTO, 050810229 (2012) PENGARUH PENGIKAT GELATIN 1% DAN 2% TERHADAP MUTU FISIK DAN DISOLUSI ORALLY DISINTEGRATING TABLET PARASETAMOL DENGAN DISINTEGRAN POLYPLASDON XL-10 5% (Dibuat dengan Basis Manitol dan Metode Freeze Drying). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Orally disintegrating tablet (ODT) are gaining attractiveness over conventional tablets especially for patients having difficulty in swallowing such as pediatric, geriatric, bedridden and disable. However, the requirements of formulating these dosage forms with mechanical strength sufficient to withstand the rigors of handling and capable of disintegrating within a few seconds on contact with saliva are inextricable. Paracetamol, an antipyretic medication, was used as a model drug in the formulated ODT. Therefore, the aim of this study was to determine the effect of of gelatin 1% and 2% as a binding agent on the physical characteristics (hardness, friablitiy, disintegration time) and dissolution of paracetamol ODT made by freeze drying. Tablet were evaluated for hardness, friability, disintegration time, and dissolution. The results showed that mechanical strength of the tablet increased by increasing of gelatin concentration but there was no significant difference in dissolution result . The hardness of tablet prepared using gelatin 2% was significantly improved compared to tablet prepared using gelatin 1%. The friability of tablet prepared using gelatin 1% and 2% were less than 1%. All of the formula showed disintegration time less than 60 seconds and percent dissolved within 30 minutes more than 80%.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F.24/13 Ari p
Uncontrolled Keywords: ORALLY DISINTEGRATING TABLET, PARACETAMOL, GELATIN
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
ARFIAN ARIANTO, 050810229UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorBambang Widjaja, Drs., Apt., M.SiUNSPECIFIED
Depositing User: mat sjafi'i
Date Deposited: 14 Feb 2013 12:00
Last Modified: 02 Sep 2016 05:12
URI: http://repository.unair.ac.id/id/eprint/9099
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