KARAKTERISASI SEDIAAN DAN UJI PELEPASAN NATRIUM DIKLOFENAK DENGAN SISTEM MIKROEMULSI W/O DARI BASIS GEL HPC (Mikroemulsi W/O dengan Surfaktan Span 80-Tween 80 : Kosurfaktan Etanol 96% = 6 : 1)

DEENA RISMAYAKA ASMARADHANI, 050810182 (2012) KARAKTERISASI SEDIAAN DAN UJI PELEPASAN NATRIUM DIKLOFENAK DENGAN SISTEM MIKROEMULSI W/O DARI BASIS GEL HPC (Mikroemulsi W/O dengan Surfaktan Span 80-Tween 80 : Kosurfaktan Etanol 96% = 6 : 1). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The present study was made to characterized the dosage form and to investigate the release profile of diclofenac sodium. The pseudo ternary phase diagrams for the combination of soybean oil, water, and Span 80 and Tween 80 : ethanol 96% = 6/1was used to make the microemulsion formula. Microemulsion obtained was mixed with gel base consisted of HPC and propylenglycol, as formula I. Formulation of diclofenac sodium emulsion gel based was used as control formula (formula II). The result of characterization showed that formula I had thicker consistency than formula II. PH of formula I was 6.77±0.03 and formula II was 6.73±0.05. Spread diameter of zero load for formula I was 6.62 ± 0.06 cm and formula II was 12.97 ± 0.60 cm. Dissolution test was carried out to evaluate diclofenac sodium realease, the result of this test is flux of diclofenac sodium. The rate of diclofenac sodium flux of formula I was 47.3409±0.2546 per cm2 per minute1/2.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F.29/13 Asm k
Uncontrolled Keywords: DICLOFENAC SODIUM, MICROEMULSION, DRUG RELEASE
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsEmail
DEENA RISMAYAKA ASMARADHANI, 050810182UNSPECIFIED
Contributors:
ContributionNameEmail
UNSPECIFIEDEsti Hendradi, Dra. Hj., Apt.,M.Si,Ph.DUNSPECIFIED
Depositing User: mat sjafi'i
Date Deposited: 14 Feb 2013 12:00
Last Modified: 02 Sep 2016 06:46
URI: http://repository.unair.ac.id/id/eprint/9104
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