STUDI PRAFORMULASI PENGARUH SUHU TERHADAP STABILITAS KIMIA Asam p-metoksisinamat

ANDHI SETYAWAN, 050810274 (2012) STUDI PRAFORMULASI PENGARUH SUHU TERHADAP STABILITAS KIMIA Asam p-metoksisinamat. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

APMS stability test has been studied by increasing temperature test method. Assay of APMS in citrate buffer solution at pH 6.0 has been done at 50o, 70o and 80o C performed by HPLC method at 286 nm as λmax. Used a mobile phase of methanol: water in the ratio 55: 45. Obtained degradation rates constants (k) 1,382 x 10-3 hour-1 at 50o C, 3,532 x 10-3 hour-1 at 70o C and 4,323 x 10-3 hour-1 at 80o C. Value of (k) at 25o C (k25) by extrapolating the regression equation for the temperature at 4,445 x 10-4 hour-1 and (k25) rates based on the Arrhenius equation by using a comparison of the results obtained k50 4,284 x 10-4 hour-1.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F.31/13 Set s
Uncontrolled Keywords: AMPS, STABILITY TEST, THE CONSTANT DEGRADATION
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsEmail
ANDHI SETYAWAN, 050810274UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorNoorma Rosita, Dra., Msi., Apt.UNSPECIFIED
Depositing User: mat sjafi'i
Date Deposited: 14 Feb 2013 12:00
Last Modified: 02 Sep 2016 07:14
URI: http://repository.unair.ac.id/id/eprint/9106
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