KARAKTERISASI ORALLY DISINTEGRATING TABLET PARASETAMOL DENGAN DISINTEGRAN POLYPLASDONE XL-10 5% DAN 10% MENGGUNAKAN PENGIKAT GELATIN 2% (Dibuat dengan Basis Manitol dan Metode Freeze Drying)

ZAHAR KURNIA TASLIM, 050810185 (2012) KARAKTERISASI ORALLY DISINTEGRATING TABLET PARASETAMOL DENGAN DISINTEGRAN POLYPLASDONE XL-10 5% DAN 10% MENGGUNAKAN PENGIKAT GELATIN 2% (Dibuat dengan Basis Manitol dan Metode Freeze Drying). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Paracetamol (acetaminophen) is an active metabolite of phenacetin with antipyretic and analgesic properties. Orally disintegrating tablets of paracetamol were prepared by freeze drying method using mannitol based excipient. This study aims to determine the characterization of paracetamol orally disintegrating tablet (ODT) using polyplasdone XL-10 5% and 10% as disintegrant and gelatin 2% as binder. Freeze dried ODT, physical mixture, and single compounds were characterized using powder X-ray diffractometry (PXRD), differential thermal analysis (DTA), and Scanning Electron Microscope (SEM). PXRD study indicated that there was a decrease in degree of crystallinity of paracetamol in freeze dried ODT compared to physical mixture. DTA study showed that there was a decrease of melting point in the freeze dried ODT but the enthalpy of paracetamol could not be determined because overlapping of endothermic peaks occurred between paracetamol and other excipients. The lowest degree of crystallinity of paracetamol and melting point was showed by formulation containing polyplasdone XL-10 10%. The characterization using SEM showed that tablets prepared by freeze drying method were porous, even though the porosity among all formulations could not be directly determined visually

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F.34/13 Tas k
Uncontrolled Keywords: ORALLY DISINTEGRATING TABLET, PARACETAMOL, POLYPLASDONE XL-10, GELATIN
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
ZAHAR KURNIA TASLIM, 050810185UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorBambang Widjaja, Drs., Apt., M.SiUNSPECIFIED
Depositing User: mat sjafi'i
Date Deposited: 14 Feb 2013 12:00
Last Modified: 02 Sep 2016 09:16
URI: http://repository.unair.ac.id/id/eprint/9109
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