PENGARUH KONSENTRASI CARBOXYMETHYL CHITOSAN TERHADAP KARAKTERISTIK FISIK DAN PROFIL PELEPASAN MIKROPARTIKEL KETOPROFEN-CARBOXYMETHYL CHITOSAN (Dibuat dengan metode spray drying)

WINI LESTARI, 050810018 (2012) PENGARUH KONSENTRASI CARBOXYMETHYL CHITOSAN TERHADAP KARAKTERISTIK FISIK DAN PROFIL PELEPASAN MIKROPARTIKEL KETOPROFEN-CARBOXYMETHYL CHITOSAN (Dibuat dengan metode spray drying). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Microparticles of ketoprofen-carboxymethyl chitosan could be developed to extend absorption and decrease gastric irritation. The aim of this research is to investigate the effect of carboxymethyl chitosan concentration (0,125%, 0,250%, 0,375%, and 0,750%) on physical characteristic, drug content, and drug release of ketoprofen-carboxymethyl chitosan microparticles. Microparticle was prepared by ionic gelation using CaCl2 as cross linker, and dried by spray drying method. The result showed that as the carboxymethyl chitosan concentration increased, the mean particle size of microparticles and the entrapment efficiency of the drugs increased. In simulated intestinal fluid, the release ketoprofen in microparticles was slower than ketoprofen control

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F.42/13 Les p
Uncontrolled Keywords: KETOPROFEN, CARBOXYMETHYL CHITOSAN
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
WINI LESTARI, 050810018UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorRetno Sari, Dra., M.Sc., AptUNSPECIFIED
Depositing User: mat sjafi'i
Date Deposited: 14 Feb 2013 12:00
Last Modified: 02 Sep 2016 11:16
URI: http://repository.unair.ac.id/id/eprint/9117
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