KARAKTERISASI SEDIAAN DAN PELEPASAN NATRIUM DIKLOFENAK DENGAN SISTEM MIKROEMULSI TIPE W/O (Perbandingan Konsentrasi Surfaktan (Span 80-Tween 80): Kosurfaktan (Etanol 96%) = 6:1 dalam basis gel HPMC 4000)

NAILUL GHAYAH, 050810171 (2013) KARAKTERISASI SEDIAAN DAN PELEPASAN NATRIUM DIKLOFENAK DENGAN SISTEM MIKROEMULSI TIPE W/O (Perbandingan Konsentrasi Surfaktan (Span 80-Tween 80): Kosurfaktan (Etanol 96%) = 6:1 dalam basis gel HPMC 4000). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of this study was to observe the characteristics of dosage form and release of diclofenac sodium with microemulsion w/o system in HPMC 4000 gel base. The ratio of surfactant (Span 80-Tween 80): cosurfactant (ethanol 96%) = 6:1 was used to make microemulsion. Diclofenac sodium with emulsion in gel base was used as comparator. The evaluation included organoleptic, pH, spread diameter measurement of zero load, and also diclofenac sodium release test from gel base of each formula. Data from pH test, spread diameter measurement of zero load, and flux of drug release test were evaluated based on independent sample t-test. Data analysis showed that pH for microemulsion system in gel base (formula I) was 6.59±0.006 and emulsion system in gel base (formula II) was 6.55±0.047. Spread diameter measurement of zero load for formula I was 7.5±0.10 cm and for formula II was 12.7±0.21 cm. Those data was analyzed by statistic programme of SPSS using independent sample t-test with degree of confident 95% (α=0.05). The result showed that there was a significant difference between two formulas in spread diameter of zero load but no significant difference in pH. Then, drug release test was carried out with Erweka Dissolution Tester Type DT 820 with apparatus 5 paddle overdisk in phosphate buffer 7.4±0.05, temperature 32°C and paddle rotation speed 100 rpm. The rate of diclofenac sodium release in microemulsion system in gel base was 48.4414±0.5236 μg/cm2/√minute.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F.49/13 Gha k
Uncontrolled Keywords: DICLOFENAC SODIUM, MICROEMULSION, DRUG RELEASE
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
NAILUL GHAYAH, 050810171UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorHj. Esti H., Dra., Apt., M.Si, Ph.DUNSPECIFIED
ContributorTristiana E. M., Dra., Apt., M.Si.UNSPECIFIED
Depositing User: mat sjafi'i
Date Deposited: 15 Feb 2013 12:00
Last Modified: 04 Jul 2017 23:52
URI: http://repository.unair.ac.id/id/eprint/9124
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