RIDHO ROBBY IMANTA, 051511133032 (2019) VALIDASI METODE SPEKTROFOTOMETRI SERAPAN ATOM UNTUK PENETAPAN KADAR MINERAL (Mg, Mn, DAN Zn) DALAM SEDIAAN KAPLET SUPLEMEN KESEHATAN. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This study aims to validate Flame Atomic Absorption Spectrometry (FAAS) for the determination of minerals, such as Mg (magnesium), Mn (manganese) and Zn (zinc) in caplet dosage forms of health supplement. Mineral separation method was done from dry material matrix (550 ± 20 oC) using wet ashing with concentrated H2O2 solution and mixture of 6 M HCl with concentrated HNO3 (20:1). The validation method consisted of selectivity studies, linearity, detection limits (LOD), quantitation limits (LOQ), precision and accuracy. The proposed method showed good linear in the concentration ranging between 0.09 - 0.79 mg / L, 0.49 - 1.98 mg / L, 0.99 - 7.99 mg / L for Mg, Mn, and Zn, respectively. The correlation coefficient (r) obtained for this regression is higher than 0.999 and the relative process standard deviation value (Vxo) is not more than 5%. Detection limits (LOD) of Mg, Mn, and Zn were found to be 1.35×10-3 mg / L, 2.79×10-3 mg / L, and 2.47×10-2 mg / L, respectively. While the limit of quantitation (LOQ) was found to be 4.10 × 10-3 mg / L, 8.45 × 10-3 mg /L, and 7.50×10-2 mg / L for Mg, Mn and Zn, respectively. This method is successfully applied for determining minerals e.g. Mg, Mn and Zn in caplet dosage forms of health supplements.

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