Rahma Putri Anggraini and Dewa Ketut Meles and Eka Pramyrtha Hestianah and Wurlina (2017) Aktivitas Alkaloid Daun Jarong (Achyranthes aspera Linn) Terhadap Kematian Sel Kanker Mammae (Mus musculus). Veterinaria Medika, 10 (2). pp. 159-165. ISSN 1979-1305

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Abstract

The purpose of this study was to describe activity of alkaloid of jarong leaves (Achyranthes aspera Linn ) on the death of cancer cells in the breasts cancer of mice (Mus musculus). Twenty four mice were divided into six treatment groups which each group consists of four mice, K- as control were induced CMC Na 0,5%, meanwhile K+, P0, P1, P2, and P3 were induced with Benzo[a]pyrene, and then given alkaloid of jarong leaves (Achyranthes aspera Linn ) and metotreksat for positive control. Sacrified and staining at weeks as seventeen and eighteen. The data of apoptosis and necrosis breast cancer cells was analyzed using One wayAnova test and continued by Honestly Significant Difference test. The result of this study showed there were significant (p<0,05), but between positive control and P1,P2,P3 given same effect in apoptosis and necrosis incident of breast cancer death. The present study shows that alkaloid of jarong leaves (Achyranthes aspera Linn) has a therapeutic dose almost similar to metotreksat. Keywords : Alkaloid, Achyranthes aspera Linn, breast cancer, mice

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