KHUN NAY WIN TUN (2019) EVALUATION OF ANTIOXIDANT, ANTIDIABETIC, AND CYTOTOXIC ACTIVITIES OF THE SECONDARY METABOLITE COMPOUNDS FROM THE THREE PLANTS SPECIES COLLECTED IN TAUNGGYI REGION (MYANMAR). Disertasi thesis, Universitas Airlangga.

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Abstract

The present study describes the isolation and structure elucidation of secondary metabolite compounds from Myanmar medicinal plants. Thirteen known compounds were identified from the stem bark of Casimiroa edulis, four were discovered for the first time from this genus. At the same time, three known sesquiterpenes, and a phenylpropanoid were isolated from the rhizomes of Curcuma comosa and Asparagus racemosus. Their structures were identified by comparison of experimental and published spectroscopic data. Some isolated compounds were evaluated for their antioxidant activity using the DPPH assay. All of them were showed no significant activity. Compounds KNWT-1 to KNWT-7, KNWT-14, 15, and 16 were evaluated for their cytotoxicity against HeLa and T47D cell lines. KNWT-2, 7, 15, 16 showed moderate cytotoxic activity with IC50 value in the ranging from 10.93-77.18 g/mL. Although all isolated compounds were known, this was the first phytochemical study from Taunggyi medicinal plants.

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