KARAKTERISASI SISTEM LIPOSOM KERING KURKUMIN YANG DIBUAT DARI EGG PHOSPHATIDYLCHOLINE DAN HYDROGENATED EGG PHOSPHATIDYLCHOLINE

NI LUH WAHYU PURNAMI, 051111006 (2016) KARAKTERISASI SISTEM LIPOSOM KERING KURKUMIN YANG DIBUAT DARI EGG PHOSPHATIDYLCHOLINE DAN HYDROGENATED EGG PHOSPHATIDYLCHOLINE. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Curcumin has poor solubility in aqueous media and permeability through membrane, so it has been classified as BCS Class IV. Liposome encapsulation of curcumin would increase its solubility and bioavailability. This study aimed to investigate the physical characterization of curcumin liposome such as particle size, thermal properties, X-ray diffraction pattern, and morphology. Egg Phosphatidylcholine (EPC) and Hydrogenated Egg Phosphatidylcholine (HEPC) were selected as phospholipids to form different types of curcumin-loaded liposomes: Cur-EPC-L (curcuminloaded EPC liposome) and Cur-HEPC-L (curcumin-loaded HEPC liposome). Thin-film hydration method was selected to prepare liposome. Curcumin liposome was dried prior to characterization. The physical properties of different liposome were investigated in follow: the average particle sizes of the two types of curcumin liposome were 2396.5 ± 979.4nm (Cur-EPC-L) and 2464.2 ± 1813.0nm (Cur-HEPC-L), respectively. The result of thermal analysis showed that there was not separation of curcumin among all materials in both formulas. The pattern of X-ray diffraction showed that there was not crystallization of materials in both the formula, indicated that curcumin was in amorphous state. Based on morphology results, both liposome formulas have a spherical shape. These results suggest that EPC and HEPC could be used in curcumin liposome formulation as they have good physical characteristics and potentially developed to increase the bioavailability of curcumin.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F.22/15 Pur k
Uncontrolled Keywords: liposome, curcumin, phosphatidylcholine, EPC, HEPC
Subjects: Q Science > QD Chemistry > QD1-999 Chemistry
Q Science > QK Botany > QK1-989 Botany
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
NI LUH WAHYU PURNAMI, 051111006UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorHelmy Yusuf, SSi., M.Sc., Ph.D., AptUNSPECIFIED
ContributorRetno Sari, Dr., M.Sc., AptUNSPECIFIED
Depositing User: Nn Dhani Karolyn Putri
Date Deposited: 19 Feb 2016 12:00
Last Modified: 04 Oct 2016 10:37
URI: http://repository.unair.ac.id/id/eprint/9274
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