PENGARUH pH TERHADAP KELARUTAN SALISILAMIDA

FIRDAUSIAH FANIA DWI PUTRI, 051111211 (2015) PENGARUH pH TERHADAP KELARUTAN SALISILAMIDA. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The influence of pH upon solubility of salicylamide, a weak acid which has analgesic and antipyretic activity, as a preformulation study of physico chemical properties before its further development as pharmaceutical dosage form has been investigated. Solubility of drug could affect its absorption in the gastrointestinal tract and also during penetration of drugs through the stratum corneum. As a weak acid, salicylamide solubility is thoroughly influenced by pH. To determine the solubility of salicylamide, saturated solubility of salicylamide were performed. Determination solubility of salicylamide was performed at pH ranges of 2.0 – 11.0. The result suggest that an increase of pH from 2.0 to 10.0 would also increase salicylamide solubility, but at pH 11.0 salicylamide solubility were declined as shown in the profile. The decrease of salicylamide solubility in pH 11.0 caused by specific base catalysis. Therefore, it is strongly suggested to investigate the influence of pH upon salicylamide stability.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: SALICYLAMIDE; INFLUENCE
Subjects: Q Science > QD Chemistry > QD1-999 Chemistry
R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
FIRDAUSIAH FANIA DWI PUTRI, 051111211UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDewi Isadiartuti, Dr., Apt., M.SiUNSPECIFIED
ContributorNoorma Rosita, Dr., Apt., M.SiUNSPECIFIED
Depositing User: Nn Dhani Karolyn Putri
Date Deposited: 19 Feb 2016 12:00
Last Modified: 29 Sep 2016 14:31
URI: http://repository.unair.ac.id/id/eprint/9281
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