UJI AKTIVITAS ANTIHIPERKOLESTEROL EKSTRAK KERING DAUN AFRIKA (Vernonia amygdalina Delile) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN DAN DIET TINGGI KOLESTEROL

AINA AL MARDHIYAH, 051111173 (2015) UJI AKTIVITAS ANTIHIPERKOLESTEROL EKSTRAK KERING DAUN AFRIKA (Vernonia amygdalina Delile) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN DAN DIET TINGGI KOLESTEROL. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Hypercholesterolemia is a disease of cholesterol metabolism disorder. Conventional drug therapy reported to have side effects in long term use. The purpose of this research was to study the role of bitter leaf (Vernonia amygdalina) ethanol dry extract in lowering cholesterol and LDL levels. 30 mice (Mus musculus) were divided into six groups of five mice each. Positive control group was treated with Atorvastatin 0,026mg/ 20g BB, negative control group was given cornstarch and microcell suspension, group 1, group 2, and group 3 were treated with 5,6mg/ 20g, 8,4mg/ 20g, and 11,2mg/ 20g body weight of the dry ethanolic extract of Vernonia amygdalina, treatment was given daily for 7 days. To induced hypercholesterol, mice was fasted for 18h, alloxan monohydrate was given by intraperitoneal injections and fed on high-cholesterol diet. Prior to injection, alloxan was dissolved in citrate buffer (0,05M, pH 4,5). Positive control group showed reduction of 76 mg/dL (±15,2381), group D1 showed reduction of 18 mg/dL (±9,2032), group D2 showed reduction of 13,2 mg/dL (±12,1383), group D3 showed reduction of 16,2 mg/dL (±2,7821). Data obtained was subjected to one-way analysis of variance followed by LSD test to determine the statistical significant of change in blood cholesterol level. There was no group that has significant difference with negative control groups (α= 0,05).

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FT.14/15 Mar u
Uncontrolled Keywords: Vernonia amygdalina Delile, antihypercholesterol, alloxan induced, high-cholesterol diet, atorvastatin
Subjects: Q Science > QD Chemistry > QD415-436 Biochemistry
R Medicine > RC Internal medicine > RC31-1245 Internal medicine
S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsEmail
AINA AL MARDHIYAH, 051111173UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorSukardiman, Prof., Dr., M.S, Apt.UNSPECIFIED
Depositing User: Nn Dhani Karolyn Putri
Date Deposited: 22 Feb 2016 12:00
Last Modified: 21 Sep 2016 02:45
URI: http://repository.unair.ac.id/id/eprint/9294
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