AKTIVITAS PENGHAMBATAN VIRUS INFLUENZA A SUBTIPE H5N1 (FLU BURUNG) EKSTRAK METANOL BUAH Brucea javanica (L.) Merr.

AZZIYAN WALIDAH, 051111014 (2015) AKTIVITAS PENGHAMBATAN VIRUS INFLUENZA A SUBTIPE H5N1 (FLU BURUNG) EKSTRAK METANOL BUAH Brucea javanica (L.) Merr. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Avian influenza A H5N1 known as highly pathogenic avian influenza (HPAI) which continues to cause human disease with high mortality and become the threat of a pandemic. Recent investigation has been found some resistance of antiviral agent used against H5N1. This has raised concern to found new antiviral agents to fight and decrease the number of death caused by this virus. Natural products has been discovered as a potential resources of novel antiviral agents. Brucea Javanica (L.) Merr., is a medicinal plant which has been reported to have an antiviral activity against some viruses. This research has been done to investigate the activity of methanolic extract of Brucea javanica (L.) Merr. fruit against the H5N1 virus which inoculated in embryonated chicken egg. In this model, the virus and extract were mixed and injected into the allantoic cavity of embryonated chicken egg. The concentration of extract used in this research are 62.5 μg/ml, 125 μg/ml and 250 μg/ml. The virus titer in the allantoic fluid was titrated by the hemagglutination assay after incubation for 72 h at 37°C and 12 h at 4 °C.It has been found that extract with the concetration 62.5 μg/ml, 125 μg/ml and 250 μg/ml decreased the hemagglutination titers as compared to non treated group and shown inhibition about 6.1%, 42.4%, and 78.8% respectively. This study showed that methanolic extract of Brucea javanica (L.) Merr. fruit has antiviral activity against avian influenza H5N1 virus in this models.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FT.15/15 Wal a
Uncontrolled Keywords: Influenza A virus, H5N1, Avian influenza, antiviral, Brucea javanica (L.) Merr.
Subjects: Q Science > QD Chemistry > QD415-436 Biochemistry
Q Science > QR Microbiology > QR355 Virology
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsEmail
AZZIYAN WALIDAH, 051111014UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorNeny Purwitasari, S.Farm., M.ScUNSPECIFIED
ContributorEma Qurnianingsih, dr., M.SiUNSPECIFIED
Depositing User: Nn Dhani Karolyn Putri
Date Deposited: 22 Feb 2016 12:00
Last Modified: 21 Sep 2016 02:45
URI: http://repository.unair.ac.id/id/eprint/9295
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