EFEK EKSTRAK ETANOL 90% DAUNCassia spectabilis TERHADAP Plasmodium berghei SECARA In Vivo

NINDYA TRESIANA PUTRI, 051111098 (2015) EFEK EKSTRAK ETANOL 90% DAUNCassia spectabilis TERHADAP Plasmodium berghei SECARA In Vivo. Skripsi thesis, UNIVERSITAS AIRLANGGA.


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Malaria is an infectious disease caused by Plasmodium sp. Medicinal plants have contributed significantly to current malaria treatment. One of the herbs that are potential as an antimalarial is Cassia spectabilis. The purpose of this research was to investigate the effect of 90% ethanolic extract of Cassia spectabilis leaves against Plasmodium berghei in vivo. In this research, the powdered leaves were extracted by maceration using 90% ethanol. The ethanolic extract of Cassia spectabilis leaves was tested in vivo as antimalarial agent using Peter’s 4 day suppresive test. Albino mice (19-31 body weight) were infected with Plasmodium berghei intra peritoneally with suspension containing infected red blood cell taken from donor mice with parasitemia >20%, when parasite concentration in erythrocyte reached 1-2%, treatment with suspension extract was given for four consecutive days orally with doses 50, 75, 100, 150, 200, and 250 mg/kg mice body weight. Thin blood films prepared from the tail of each mice were used to determine parasitemia level for five days and compared to non treated subjects and ED50 was obtained by analyzing inhibition level in five days with probit analysis. The result showed that 90% ethanolic extract of Cassia spectabilis leaves has an ED50 131,5 mg/kg body weight against Plasmodium berghei.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FT.41/15 Put e
Uncontrolled Keywords: Cassia spectabilis, Plasmodium berghei, 4-day suppresive test, antimalarial
Subjects: Q Science > QD Chemistry > QD1-999 Chemistry
Q Science > QK Botany > QK1-989 Botany
Q Science > QR Microbiology > QR75-99.5 Bacteria
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
ContributorWiwied Ekasari, Dr., M.SiUNSPECIFIED
ContributorSuciati, S.Si., M.Phil., Ph.DUNSPECIFIED
Depositing User: Nn Dhani Karolyn Putri
Date Deposited: 25 Feb 2016 12:00
Last Modified: 21 Sep 2016 02:56
URI: http://repository.unair.ac.id/id/eprint/9321
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