PENGARUH PEMBERIAN EKSTRAK ETANOL 90% DAUN Cassia spectabilis TERHADAP PERBAIKAN FUNGSI HEPAR MENCIT JANTAN TERINFEKSI Plasmodium berghei

ANISAH MAHARDIANI, 051111026 (2015) PENGARUH PEMBERIAN EKSTRAK ETANOL 90% DAUN Cassia spectabilis TERHADAP PERBAIKAN FUNGSI HEPAR MENCIT JANTAN TERINFEKSI Plasmodium berghei. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Malaria is one of major problem around the world especially in tropical and subtropical areas with estimated one million deaths annually. Therefore, finding the new medicinal plant to protect people from malaria was urgently needed. The previous research had shown that Cassia spectabilis leaves extract and fraction have potential antimalarial activity in vitro. Hence, effect of Cassia spectabilis on liver protection in this study during Plasmodium berghei infection in mice was investigated. For in vivo study, selected mice (25-35 g body weight) were devided into 5 groups, each consist of 4 mice.Mice were given oral doses of CMC Na 0.5% suspension with 150 mg/Kg BW mice, 200 mg/Kg BW mice, chloroquin 100 mg/Kg BW daily for 4 days. One group treated with 0.5% CMC Na solution as negative control. A healthy mice without infection of Plasmodium berghei for healthy group use as comparation. Each mice BALB/c strains were infected with parasitized erythrocytes of Plasmodium berghei ANKA by intraperitonial injection. The 90% ethanol Cassia spectabilis leaves extract dose 200mg/Kg bw mice treatment significantly reduced the serum levels of SGOT, SGPT and the liver damage of mice. The study suggests that 90% ethanol Cassia spectabilis leaves extract dose 200mg/Kg BW mice protect the liver mice during the infection of Plasmodium berghei.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FT.43/15 Mah p
Uncontrolled Keywords: Extract of Cassia spectabilis Leaves, Plasmodium berghei, liver, SGOT, SGPT
Subjects: Q Science > QD Chemistry > QD1-999 Chemistry
Q Science > QR Microbiology > QR75-99.5 Bacteria
S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals
S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > SF811-909 Veterinary medicine of special organs, regions, and systems
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsEmail
ANISAH MAHARDIANI, 051111026UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorWiwied Ekasari, Dr., Apt., M.SiUNSPECIFIED
ContributorNeny Purwitasari, S.Farm., M.ScUNSPECIFIED
Depositing User: Nn Dhani Karolyn Putri
Date Deposited: 25 Feb 2016 12:00
Last Modified: 21 Sep 2016 02:57
URI: http://repository.unair.ac.id/id/eprint/9323
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