EFEK GASTROPROTEKTIF ANTIDEPRESAN FLUVOXAMINE TERHADAP GASTRIC ULCER YANG DIINDUKSI OLEH STRES DAN NSAID

AYU RATNASARI, 051111082 (2015) EFEK GASTROPROTEKTIF ANTIDEPRESAN FLUVOXAMINE TERHADAP GASTRIC ULCER YANG DIINDUKSI OLEH STRES DAN NSAID. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Gastric ulcer is a localized area of destruction on mucosal gastric resulted by necrotic mucosa and appears as erosion or ulcer. Many antidepressant drugs have shown antiulcer activity in various ulcer models by enhancing antioxidant and decreasing oxidant parameter, experimentally. The aim of this study was to investigate the gastroprotective effect of fluvoxamine in gastric ulcer induced by stress and NSAID. Mechanism underlying this effect was evaluated by assessing stress oxidative marker, malondialdehyde (MDA). This study showed that fluvoxamine had gastroprotective effect in gastric ulcer induced by stress and NSAID. Fluvoxamine dose 100 mg/kg significantly decreased ulcer index in gastric ulcer induced by stress (p = 0,0090) and gastric ulcer induced by NSAID (p = 0,0443). It also decreased intraluminal bleeding in gastric ulcer induced by stress (p = 0,0243). While fluvoxamine 50 mg/kg significantly decreased ulcer index in gastric ulcer induced by stress only (p = 0,0449) and had small effect on intraluminal bleeding. However, fluvoxamine did not decrease malondialdehyde (MDA) level in gastric tissue.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FK.18/15 Rat e
Uncontrolled Keywords: gastric ulcer, stress, NSAID, MDA, fluvoxamine, index ulcer, intraluminal bleeding
Subjects: B Philosophy. Psychology. Religion > BF Psychology > BF511-593 Emotion, Feeling, Affection
R Medicine > RC Internal medicine > RC799-869 Diseases of the digestive system. Gastroenterology
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
CreatorsNIM/NIDN
AYU RATNASARI, 051111082UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorMahardian Rahmadi, S.Si., M.Sc., Ph.D., AptUNSPECIFIED
ContributorToetik Aryani, Dra., M.Si., AptUNSPECIFIED
Depositing User: Nn Dhani Karolyn Putri
Date Deposited: 29 Feb 2016 12:00
Last Modified: 21 Sep 2016 03:05
URI: http://repository.unair.ac.id/id/eprint/9342
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