Suciati and Achmad Fauzi and Myrna Adianti and Achmad Fuad Hafid (2018) Potency of a Marine Sponge From the Genus Stylissa as Anti Hepatitis C Agent. Malaysian Applied Biology, 47 (3). pp. 121-127. ISSN 0126-8643

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Abstract

Marine sponges have shown potential as a source of many bioactive metabolites. Our previous study on Indonesian marine sponges indicated that this organism possessed promising antiviral activity. The aim of this study was to screen antiviral activity of marine sponge extract from the genus Stylissa and its fractions against hepatitis C virus (HCV). Identification of metabolites in the active fractions was also carried out as well as investigation of the mode of action of the extract. The results showed that the extract inhibited the growth of HCV at IC50 of 4.4 μg/mL. The time of addition experiment revealed that the extract act at the post entry step. Bioassay-guided fractionations revealed two active fractions, namely fractions SF7 and SF8 which gave 99.3% and 86.4% inhibition, respectively, at a concentration of 50 μg/mL. 1H NMR and GC-MS analyses indicated the presence of a mixture of saturated and unsaturated fatty acids in the active fractions.

Item Type:	Article
Uncontrolled Keywords:	Marine sponge, Stylissa, hepatitis C virus, fatty acids
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi
Creators:	Creators NIM Suciati NIDN0004117905 Achmad Fauzi UNSPECIFIED Myrna Adianti NIDN0001038207 Achmad Fuad Hafid NIDN0012125207
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	24 Jan 2020 07:02
Last Modified:	04 Feb 2020 08:32
URI:	http://repository.unair.ac.id/id/eprint/93616
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