Noorma Rosita and Widji Soeratri (2016) Increasing of Lycopene's Antioxidant Stability In Solid Lipid Nanoparticle (SLN) and Nanostrcture Lipid And Carrier (NLC) in Use As Antiaging. In: Proceeding The 4th Current Drug Development International Conference (CDD 2016). Faculty of Pharmaceutical Sciences, Princes of Songkla University, Songkhla, pp. 225-228. ISBN 978-616-271-303-3

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Abstract

Lykopene is known as lipophilic antioxidant are often used as an anti-aging cosmetic active ingredient. Antioxidants is easily degraded so that its activity is reduced. To improve the stability, lycopene was loaded in nanolipid structure, such as: Solid Lipid nanoparticles (SLN) and Nanostructrure lipid carrier (NLC). Lycopene loaded in SLN and NLC arc made with High Shear homogenisation (HSH) method. An antioxidant stability is determined based on IC50 value changes. IC50 is determined using l , l -Diphenyl-2-picrylhydrazyl (DPPH) after being kept in controlled conditions on days 1 and 30. Their oclusivity was determined also. The conclusion is the NLC is able to improve the stability of the lycopene antioxidant and have oclusivity greater than the SLN. Oclusivity nature can indicate the ability of the formula to retain skin moisture.

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