Hesti Ismarini and Iswan Abbas Nusi and Ummi Maimunah and Poernomo Boedi Setiawan and Herry Purbayu and Titong Sugihartono and Ulfa Kholili and Budi Widodo and Husin Thamrin and Muhammad Miftahussurur and Amie Vidyani (2019) Helicobacter pylori density and expression of gastric mucosal interleukin-8 in dyspeptic patients. New Armenian Medical Journal, 13 (1). pp. 40-47. ISSN 18290825

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Abstract

Background: The density of the H. pylori colonies is associated with more severe clinical manifestations, chronic infections, ineffective therapy responses and malignant events. Interleukin-8 (IL-8) is one of cytokines that plays a role in the inflammatory process that results in gastric mucosal damage. We determined the association between H. pylori density and gastric mucosal IL-8 expression in dyspeptic patients. Methods: H. pylori density was determined using histopathology based on Updated Sydney System. IL-8 levels were measured using immunohistochemistry from the gastric biopsy. Results: There was significant difference between gastric mucosal IL-8 expression obtained in gastric mucosal gland epithelium (p = 0.028) at mild and high density of H. pylori (p = 0.013). There was a correlation between H. pylori density with gastric mucosal IL-8 expression of glandular epithelium (r = 0.622; p = 0.004), surface epithelium (r = 0.510; p = 0.026), and inflammatory cells (r = 0.054; = 0.028). Conclusion: We found a significant positive correlation between H. pylori density and gastric mucosal IL-8 expression in dyspeptic patients. © 2019, Yerevan State Medical University. All rights reserved.

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